Prolonged remission induced by cyclosporine in a patient with familial thrombocytopenia and enteropathy

Détails

ID Serval
serval:BIB_C5F7FC480901
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Prolonged remission induced by cyclosporine in a patient with familial thrombocytopenia and enteropathy
Périodique
Pediatric Hematology and Oncology
Auteur⸱e⸱s
Nenadov Beck  M., Kuchler  H., Roulet  M., Beck  D.
ISSN
0888-0018 (Print)
Statut éditorial
Publié
Date de publication
06/1995
Volume
12
Numéro
3
Pages
289-93
Notes
Case Reports Journal Article --- Old month value: May-Jun
Résumé
A 21-year-old patient, since the age of 16, presented a familial type of chronic autoimmune thrombocytopenia that responded only partially to various types of immunosuppressive treatment. His prolonged survival, compared to his decreased siblings, was complicated by the appearance of a severe enteropathy. High doses of corticosteroids induced a type 1 diabetes as a major side effect. The introduction of cyclosporine resulted in both a continuous complete clinical remission and a partial hematological remission and allowed the discontinuation of all other medication for 18 months. In uncommon complex autoimmune disease, cyclosporine may represent a safe and effective alternate therapy when other immunosuppressive agents have failed.
Mots-clé
Adult Autoimmune Diseases/*drug therapy Common Variable Immunodeficiency/drug therapy Cyclosporine/*therapeutic use Humans Intestinal Diseases/*drug therapy Male Thrombocytopenia/*drug therapy
Pubmed
Web of science
Création de la notice
24/01/2008 20:33
Dernière modification de la notice
20/08/2019 15:41
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