Targeting Notch signaling in pancreatic cancer.

Détails

ID Serval
serval:BIB_C5B344BAD9E2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Targeting Notch signaling in pancreatic cancer.
Périodique
Expert Opinion on Therapeutic Targets
Auteur(s)
Ristorcelli E., Lombardo D.
ISSN
1744-7631[electronic], 1472-8222[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
14
Numéro
5
Pages
541-552
Langue
anglais
Résumé
IMPORTANCE OF THE FIELD: With some 220,000 new cases/year in the world, pancreatic adenocarcinoma is the fourth highest cause of death by cancers. Among newly diagnosed patients about 210,000 will die within 9 months following diagnosis. Therefore, effective adjuncts to current treatment strategies are necessary. Because embryological signaling pathways are upregulated in pancreatic adenocarcinoma, they represent potential targets for future therapies. AREAS COVERED IN THIS REVIEW: Our aim is to present the Notch pathway, and to describe its involvement in pancreatic pathophysiology/carcinogenesis. This pathway appeared as a prime target for pancreatic cancer therapy. In the light of the crosstalk of Notch with other survival/embryologic pathways, drugs affecting more than one pathway may have to be combined. WHAT THE READER WILL GAIN: Drugs against gamma-secretases could thus serve in cancer treatment and can be combined with drugs targeting survival pathways interplaying with Notch such as Hedgehog. TAKE HOME MESSAGE: Downregulation of Notch contributes to the inhibition and apoptosis of pancreatic cancer cells whereas Hedgehog inhibition will allow for enhanced delivery of drugs to the tumor. Both pathway inhibitors appear to have synergistic effects for future therapeutics for pancreatic adenocarcinoma, once safety issues of compounds are overcome.
Mots-clé
Humans, Oncogenes, Pancreatic Neoplasms/metabolism, Pancreatic Neoplasms/physiopathology, Receptors, Notch/metabolism, Signal Transduction
Pubmed
Web of science
Création de la notice
26/11/2010 12:20
Dernière modification de la notice
20/08/2019 16:41
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