Highly diverse T cell recognition of a single Plasmodium berghei peptide presented by a series of mutant H-2Kd molecules.

Détails

ID Serval
serval:BIB_C45C9CBF6E72
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Highly diverse T cell recognition of a single Plasmodium berghei peptide presented by a series of mutant H-2Kd molecules.
Périodique
Journal of immunology
Auteur⸱e⸱s
Jaulin C., Casanova J.L., Romero P., Luescher I., Cordey A.S., Maryanski J.L., Kourilsky P.
ISSN
0022-1767
Statut éditorial
Publié
Date de publication
1992
Peer-reviewed
Oui
Volume
149
Numéro
12
Pages
3990-3994
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
We have tested 21 independent CTL clones for recognition of a single peptide derived from the Plasmodium berghei circumsporozoite protein in the context of 13 mutants of the murine MHC class I molecule H-2Kd. In this series of Kd mutants, amino acid residues located on the upper surface of the alpha-helices were individually substituted by alanine. Remarkably, most clones displayed individual recognition patterns on the Kd mutants. We had previously found that this series of CTL clones was likewise highly diverse in terms of both TCR primary structure and peptide fine specificity. Our data thus reinforce the concept that multiple T cell epitopes are available on the surface of a single peptide-MHC class I complex for recognition by specific TCR.
Mots-clé
Amino Acid Sequence, Animals, Antigens, Protozoan/immunology, Cell Line, Cytotoxicity, Immunologic, Dose-Response Relationship, Immunologic, Epitopes/immunology, Flow Cytometry, H-2 Antigens/immunology, Immunity, Cellular, Mice, Molecular Sequence Data, Mutagenesis, Site-Directed, Plasmodium berghei/immunology, Protozoan Proteins/immunology, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 11:20
Dernière modification de la notice
20/08/2019 15:39
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