Acute cardiovascular effects of two central phenylethanolamine-N-methyl-transferase inhibitors in unanesthetized desoxycorticosterone-salt hypertensive rats
Détails
ID Serval
serval:BIB_C3858F32EA76
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Acute cardiovascular effects of two central phenylethanolamine-N-methyl-transferase inhibitors in unanesthetized desoxycorticosterone-salt hypertensive rats
Périodique
European Journal of Pharmacology
ISSN
0014-2999 (Print)
Statut éditorial
Publié
Date de publication
07/1984
Volume
102
Numéro
3-4
Pages
515-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 20
Research Support, Non-U.S. Gov't --- Old month value: Jul 20
Résumé
SKF 64139, an inhibitor of phenylethanolamine-N-methyltransferase (PNMT), has a marked hypotensive effect in models of sodium-dependent hypertension. The mechanism of this effect is obscure, the compound having in addition alpha-adrenoceptor blocking properties. We compared the acute effects of SKF 64139 with those of LY 134046, another PNMT inhibitor with minimal alpha-blocking capacity, in desoxycorticosterone-salt hypertensive rats. The former agent produced profound hypotension whereas the latter caused only bradycardia. Both induced a similar pronounced suppression of PNMT activity in the C1 and C2 region of the medulla oblongata. These results suggest that the alpha-adrenergic effect rather than PNMT inhibition accounts for the acute lowering of blood pressure in this model.
Mots-clé
Animals
Benzazepines/*pharmacology
Blood Pressure/drug effects
Brain/enzymology
Desoxycorticosterone
Heart Rate/drug effects
Hemodynamic Processes/*drug effects
Hypertension/chemically induced/*physiopathology
Isoquinolines/*pharmacology
Male
Phenylethanolamine N-Methyltransferase/*antagonists &
inhibitors/metabolism
Rats
Rats, Inbred Strains
*Tetrahydroisoquinolines
Pubmed
Web of science
Création de la notice
25/01/2008 10:41
Dernière modification de la notice
20/08/2019 15:38