Activated lymph nodes recruit blood borne NK cells and effector T cells: implications for adaptive T cell responses.

Détails

ID Serval
serval:BIB_C32A9D4DFA69
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Activated lymph nodes recruit blood borne NK cells and effector T cells: implications for adaptive T cell responses.
Périodique
Current Immunology Reviews
Auteur(s)
Martín-Fontecha A, Guarda G, Lanzavecchia A., Sallusto F.
ISSN
1573-3955
Statut éditorial
Publié
Date de publication
2008
Volume
4
Numéro
1
Pages
20-27
Langue
anglais
Résumé
The migration of naïve T cells to secondary lymphoid organs and their subsequent encounter with dendritic cells (DCs) ensures the efficient priming of adaptive T cell-mediated immune responses. The expression of particular sets of adhesion molecules and chemokine receptors allows effector T cells and natural killer (NK) cells to migrate to inflamed non-lymphoid tissues. Thus, the segregation of immune functions by specialized cell subsets relies in part on their migratory competence. Recent studies have shown, however, that NK cells and effector T cells can migrate to activated lymph nodes and impact on the magnitude and quality of the primary T cell response. This is in part due to inflammation-related events that modify the adhesive properties of the high endothelial venules (HEVs). In this review we highlight recent findings that challenge the current idea of the lymph node as an exclusive niche for naive T cells and underline the unique role that NK cells and effector T cells have in models of acute and chronic inflammation when recruited to peripheral lymph nodes.
Mots-clé
Inflamed lymph nodes, NK cells, effector T cells, autoimmunity
Création de la notice
13/03/2012 16:57
Dernière modification de la notice
20/08/2019 16:38
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