Neuroendocrine aspects of aging: experimental data
Détails
ID Serval
serval:BIB_C305F3EECBCD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Neuroendocrine aspects of aging: experimental data
Périodique
Hormone Research
ISSN
0301-0163
Statut éditorial
Publié
Date de publication
1989
Peer-reviewed
Oui
Volume
31
Numéro
1-2
Pages
32-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Research Support, Non-U.S. Gov't
Review
Résumé
Aging is characterized by changes in neuroendocrine/endocrine functions which are manifest in female reproductive physiology and less perceptible in other functions such as thyroid, adrenal or growth/metabolic functions. The contribution of each level of the axis - hypothalamus, adenohypophysis or peripheral tissues - is not clearly established. Functional impairments with age are recognized in the peripheral glands (gonad, thyroid, adrenal) as well as in the pituitary, but increasing evidence is accumulating for a marked contribution of the hypothalamus in the age-associated endocrine changes observed in animals and humans. In old rats, multineuronal dysfunctions are demonstrated in the hypothalamus, with a documented decline in the activity of the neurons producing dopamine and thyrotropin-releasing hormone, and to a lesser extent luteinizing hormone- and growth hormone-releasing hormones, and alterations in regulatory mechanisms of these neurons are disclosed. Moreover, impairments are observed in the processing - binding, accumulation and intracellular distribution - of hypothalamic hormones in the adenohypophysis of old rats. Taken together, these observations are supportive of the view that the neuroendocrine/endocrine changes appearing with age result from a complex balance of functional alterations occurring at each level - central and peripheral - of the axis.
Mots-clé
Adrenal Glands/physiology
Aging/*physiology
Animals
Endocrine Glands/*physiology
Growth
Rats
Reproduction
Thyroid Gland/physiology
Pubmed
Web of science
Création de la notice
11/02/2008 14:12
Dernière modification de la notice
20/08/2019 15:38