Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Détails

Ressource 1Télécharger: BIB_C2EFFD956BB3.P001.pdf (582.63 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_C2EFFD956BB3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
Périodique
PLoS Genetics
Auteur(s)
Lindgren C.M., Heid I.M., Randall J.C., Lamina C., Steinthorsdottir V., Qi L., Speliotes E.K., Thorleifsson G., Willer C.J., Herrera B.M., Jackson A.U., Lim N., Scheet P., Soranzo N., Amin N., Aulchenko Y.S., Chambers J.C., Drong A., Luan J., Lyon H.N., Rivadeneira F., Sanna S., Timpson N.J., Zillikens M.C., Zhao J.H., Almgren P., Bandinelli S., Bennett A.J., Bergman R.N., Bonnycastle L.L., Bumpstead S.J., Chanock S.J., Cherkas L., Chines P., Coin L., Cooper C., Crawford G., Doering A., Dominiczak A., Doney A.S., Ebrahim S., Elliott P., Erdos M.R., Estrada K., Ferrucci L., Fischer G., Forouhi N.G., Gieger C., Grallert H., Groves C.J., Grundy S., Guiducci C., Hadley D., Hamsten A., Havulinna A.S., Hofman A., Holle R., Holloway J.W., Illig T., Isomaa B., Jacobs L.C., Jameson K., Jousilahti P., Karpe F., Kuusisto J., Laitinen J., Lathrop G.M., Lawlor D.A., Mangino M., McArdle W.L., Meitinger T., Morken M.A., Morris A.P., Munroe P., Narisu N., Nordström A., Nordström P., Oostra B.A., Palmer C.N., Payne F., Peden J.F., Prokopenko I., Renström F., Ruokonen A., Salomaa V., Sandhu M.S., Scott L.J., Scuteri A., Silander K., Song K., Yuan X., Stringham H.M., Swift A.J., Tuomi T., Uda M., Vollenweider P., Waeber G., Wallace C., Walters G.B., Weedon M.N., Witteman J.C., Witteman J.C., Zhang C., Zhang W., Caulfield M.J., Collins F.S., Davey Smith G., Day I.N., Franks P.W., Hattersley A.T., Hu F.B., Jarvelin M.R., Kong A., Kooner J.S., Laakso M., Lakatta E., Mooser V., Morris A.D., Peltonen L., Samani N.J., Spector T.D., Strachan D.P., Tanaka T., Tuomilehto J., Uitterlinden A.G., van Duijn C.M., Wareham N.J., Hugh Watkins D.M., Waterworth D.M., Waterworth D.M., Boehnke M., Deloukas P., Groop L., Hunter D.J., Thorsteinsdottir U., Schlessinger D., Wichmann H.E., Frayling T.M., Abecasis G.R., Hirschhorn J.N., Loos R.J., Stefansson K., Mohlke K.L., Barroso I., McCarthy M.I.
ISSN
1553-7404[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
5
Numéro
6
Pages
e1000508
Langue
anglais
Résumé
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/07/2009 9:36
Dernière modification de la notice
20/08/2019 15:38
Données d'usage