Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Lindgren, C.M.; Heid, I.M.; Randall, J.C.; Lamina, C.; Steinthorsdottir, V.; Qi, L.; Speliotes, E.K.; Thorleifsson, G.; Willer, C.J.; Herrera, B.M.; Jackson, A.U.; Lim, N.; Scheet, P.; Soranzo, N.; Amin, N.; Aulchenko, Y.S.; Chambers, J.C.; Drong, A.; Luan, J.; Lyon, H.N.; Rivadeneira, F.; Sanna, S.; Timpson, N.J.; Zillikens, M.C.; Zhao, J.H.; Almgren, P.; Bandinelli, S.; Bennett, A.J.; Bergman, R.N.; Bonnycastle, L.L.; Bumpstead, S.J.; Chanock, S.J.; Cherkas, L.; Chines, P.; Coin, L.; Cooper, C.; Crawford, G.; Doering, A.; Dominiczak, A.; Doney, A.S.; Ebrahim, S.; Elliott, P.; Erdos, M.R.; Estrada, K.; Ferrucci, L.; Fischer, G.; Forouhi, N.G.; Gieger, C.; Grallert, H.; Groves, C.J.; Grundy, S.; Guiducci, C.; Hadley, D.; Hamsten, A.; Havulinna, A.S.; Hofman, A.; Holle, R.; Holloway, J.W.; Illig, T.; Isomaa, B.; Jacobs, L.C.; Jameson, K.; Jousilahti, P.; Karpe, F.; Kuusisto, J.; Laitinen, J.; Lathrop, G.M.; Lawlor, D.A.; Mangino, M.; McArdle, W.L.; Meitinger, T.; Morken, M.A.; Morris, A.P.; Munroe, P.; Narisu, N.; Nordström, A.; Nordström, P.; Oostra, B.A.; Palmer, C.N.; Payne, F.; Peden, J.F.; Prokopenko, I.; Renström, F.; Ruokonen, A.; Salomaa, V.; Sandhu, M.S.; Scott, L.J.; Scuteri, A.; Silander, K.; Song, K.; Yuan, X.; Stringham, H.M.; Swift, A.J.; Tuomi, T.; Uda, M.; Vollenweider, P.; Waeber, G.; Wallace, C.; Walters, G.B.; Weedon, M.N.; Witteman, J.C.; Witteman, J.C.; Zhang, C.; Zhang, W.; Caulfield, M.J.; Collins, F.S.; Davey Smith, G.; Day, I.N.; Franks, P.W.; Hattersley, A.T.; Hu, F.B.; Jarvelin, M.R.; Kong, A.; Kooner, J.S.; Laakso, M.; Lakatta, E.; Mooser, V.; Morris, A.D.; Peltonen, L.; Samani, N.J.; Spector, T.D.; Strachan, D.P.; Tanaka, T.; Tuomilehto, J.; Uitterlinden, A.G.; van Duijn, C.M.; Wareham, N.J.; Hugh Watkins, D.M.; Waterworth, D.M.; Waterworth, D.M.; Boehnke, M.; Deloukas, P.; Groop, L.; Hunter, D.J.; Thorsteinsdottir, U.; Schlessinger, D.; Wichmann, H.E.; Frayling, T.M.; Abecasis, G.R.; Hirschhorn, J.N.; Loos, R.J.; Stefansson, K.; Mohlke, K.L.; Barroso, I.; McCarthy, M.I.

doi:10.1371/journal.pgen.1000508

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Détails

Télécharger: BIB_C2EFFD956BB3.P001.pdf (582.63 [Ko])
Etat: Public
Version: de l'auteur⸱e

ID Serval

serval:BIB_C2EFFD956BB3

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Périodique

PLoS Genetics

Auteur⸱e⸱s

Lindgren C.M., Heid I.M., Randall J.C., Lamina C., Steinthorsdottir V., Qi L., Speliotes E.K., Thorleifsson G., Willer C.J., Herrera B.M., Jackson A.U., Lim N., Scheet P., Soranzo N., Amin N., Aulchenko Y.S., Chambers J.C., Drong A., Luan J., Lyon H.N., Rivadeneira F., Sanna S., Timpson N.J., Zillikens M.C., Zhao J.H., Almgren P., Bandinelli S., Bennett A.J., Bergman R.N., Bonnycastle L.L., Bumpstead S.J., Chanock S.J., Cherkas L., Chines P., Coin L., Cooper C., Crawford G., Doering A., Dominiczak A., Doney A.S., Ebrahim S., Elliott P., Erdos M.R., Estrada K., Ferrucci L., Fischer G., Forouhi N.G., Gieger C., Grallert H., Groves C.J., Grundy S., Guiducci C., Hadley D., Hamsten A., Havulinna A.S., Hofman A., Holle R., Holloway J.W., Illig T., Isomaa B., Jacobs L.C., Jameson K., Jousilahti P., Karpe F., Kuusisto J., Laitinen J., Lathrop G.M., Lawlor D.A., Mangino M., McArdle W.L., Meitinger T., Morken M.A., Morris A.P., Munroe P., Narisu N., Nordström A., Nordström P., Oostra B.A., Palmer C.N., Payne F., Peden J.F., Prokopenko I., Renström F., Ruokonen A., Salomaa V., Sandhu M.S., Scott L.J., Scuteri A., Silander K., Song K., Yuan X., Stringham H.M., Swift A.J., Tuomi T., Uda M., Vollenweider P., Waeber G., Wallace C., Walters G.B., Weedon M.N., Witteman J.C., Witteman J.C., Zhang C., Zhang W., Caulfield M.J., Collins F.S., Davey Smith G., Day I.N., Franks P.W., Hattersley A.T., Hu F.B., Jarvelin M.R., Kong A., Kooner J.S., Laakso M., Lakatta E., Mooser V., Morris A.D., Peltonen L., Samani N.J., Spector T.D., Strachan D.P., Tanaka T., Tuomilehto J., Uitterlinden A.G., van Duijn C.M., Wareham N.J., Hugh Watkins D.M., Waterworth D.M., Waterworth D.M., Boehnke M., Deloukas P., Groop L., Hunter D.J., Thorsteinsdottir U., Schlessinger D., Wichmann H.E., Frayling T.M., Abecasis G.R., Hirschhorn J.N., Loos R.J., Stefansson K., Mohlke K.L., Barroso I., McCarthy M.I.

ISSN

1553-7404[electronic]

Statut éditorial

Publié

Date de publication

2009

Volume

Numéro

Pages

e1000508

Langue

anglais

Résumé

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.

URN

urn:nbn:ch:serval-BIB_C2EFFD956BB30

OAI-PMH

oai:serval.unil.ch:BIB_C2EFFD956BB3

DOI

10.1371/journal.pgen.1000508

Pubmed

19557161

Web of science

000268444600004

Open Access

Oui