Effect of nitrogen mustard on natural history of right-sided streptococcal endocarditis in rabbits: role for cellular host defenses.

Détails

ID Serval
serval:BIB_C2E6AA5037FD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of nitrogen mustard on natural history of right-sided streptococcal endocarditis in rabbits: role for cellular host defenses.
Périodique
Infection and Immunity
Auteur⸱e⸱s
Yersin B.R., Glauser M.P., Freedman L.R.
ISSN
0019-9567 (Print)
ISSN-L
0019-9567
Statut éditorial
Publié
Date de publication
1982
Volume
35
Numéro
1
Pages
320-325
Langue
anglais
Résumé
Cellular host defenses are considered to be ineffective in bacterial endocarditis; the microorganisms in infected vegetations are protected from phagocytic cells by dense layers of fibrin. To test this hypothesis, nitrogen mustard-induced agranulocytosis and leukopenia were produced in rabbits with right-sided streptococcal endocarditis. The spontaneous sterilization of tricuspid infection observed in the control animals was not present in the granulocytopenic, leukopenic animals. Since the bacterium Streptococcus intermedius is not sensitive to the complement-mediated bactericidal effect of serum and since the animals were not bacteremic during the time of agranulocytosis, an inhibitory effect of the drug on local cellular host defense mechanisms is postulated. We suggest that the spontaneous sterilization of infective endocarditis in the right side of the heart in rabbits is mediated by cellular host defenses.
Mots-clé
Agranulocytosis/chemically induced, Animals, Endocarditis, Bacterial/immunology, Endocarditis, Bacterial/pathology, Granulocytes/immunology, Leukocytes/immunology, Leukopenia/chemically induced, Mechlorethamine/pharmacology, Rabbits, Streptococcal Infections/immunology, Streptococcus/isolation & purification, Tricuspid Valve/pathology
Pubmed
Création de la notice
20/02/2009 19:24
Dernière modification de la notice
20/08/2019 16:38
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