Seizure-related short-term plasticity of benzodiazepine receptors in partial epilepsy: a [11C]flumazenil-PET study

Détails

ID Serval
serval:BIB_C2A388CDAD23
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Seizure-related short-term plasticity of benzodiazepine receptors in partial epilepsy: a [11C]flumazenil-PET study
Périodique
Brain
Auteur(s)
Bouvard S., Costes N., Bonnefoi F., Lavenne F., Mauguiere F., Delforge J., Ryvlin P.
ISSN
1460-2156 (Electronic)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
06/2005
Volume
128
Numéro
Pt 6
Pages
1330-43
Langue
anglais
Notes
Bouvard, Sandrine
Costes, Nicolas
Bonnefoi, Frederic
Lavenne, Franck
Mauguiere, Francois
Delforge, Jacques
Ryvlin, Philippe
eng
Research Support, Non-U.S. Gov't
England
Brain. 2005 Jun;128(Pt 6):1330-43. doi: 10.1093/brain/awh470. Epub 2005 Mar 9.
Résumé
We have undertaken a test-re-test [11C]flumazenil (FMZ) PET study in 10 drug-resistant epileptic patients, including six with a mesiotemporal epilepsy (MTE), and 10 normal controls, in order to investigate seizure-related short-term plasticity of benzodiazepine (BZD) receptors. All subjects underwent two FMZ-PET scans at a 1 week interval. Patients benefited from a concurrent video-EEG monitoring which allowed determination of the duration of the interictal period (IP) preceding each PET. Test-re-test whole brain B'(max) variations, evaluated with a partial-saturation injection protocol, were similarly observed in patients and controls, suggesting a physiological modulation of BZD receptors. Five patients (50%), but no controls, also demonstrated clinically significant test-re-test FMZ-PET variations in the mesial temporal region. This was observed in all three patients with MTE and no hippocampal atrophy in whom only the PET study associated with the shortest IP correctly identified the epileptogenic zone. Statistical analysis revealed a significant effect of IP duration on BZD receptor B'(max) in MTE patients, suggesting that the shorter the IP, the lower the B'(max) in the epileptogenic hippocampus. FMZ-PET appears to be an interesting tool for investigating both normal and abnormal short-term modulations of the BZD receptor system, and should ideally be performed within a few days following a seizure in patients with MTE and a normal MRI.
Mots-clé
Adolescent, Adult, Carbon Radioisotopes, Drug Resistance, Electroencephalography, Epilepsies, Partial/diagnostic imaging/*metabolism, Female, Flumazenil, GABA Modulators, Hippocampus/diagnostic imaging/metabolism, Humans, Magnetic Resonance Imaging/methods, Male, Middle Aged, *Neuronal Plasticity, Positron-Emission Tomography/methods, Prospective Studies, Receptors, GABA-A/*metabolism
Pubmed
Open Access
Oui
Création de la notice
29/11/2018 12:36
Dernière modification de la notice
20/08/2019 15:37
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