Non-Hodgkin lymphoma presenting with spinal cord compression: A population-based analysis of the NHL-BFM study group.

Détails

Ressource 1Télécharger: 38961598.pdf (305.27 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_C280DEBCA9DE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Non-Hodgkin lymphoma presenting with spinal cord compression: A population-based analysis of the NHL-BFM study group.
Périodique
Pediatric blood & cancer
Auteur⸱e⸱s
Riquelme A., Werner J., Zimmermann M., von Mersi H., Kabíčková E., Ceppi F., Foerster J., Finger J., Müller S., Attarbaschi A., Burkhardt B., Woessmann W.
ISSN
1545-5017 (Electronic)
ISSN-L
1545-5009
Statut éditorial
Publié
Date de publication
09/2024
Peer-reviewed
Oui
Volume
71
Numéro
9
Pages
e31182
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Spinal cord compression is a rare presentation of non-Hodgkin lymphoma (NHL) in children. We aimed to describe the prevalence, histological subtypes, clinical presentation, therapy, and outcome of those children in a population-based cohort. The chemotherapy regimen remained comparable over time.
We retrospectively identified all children and adolescents with paresis as initial manifestations of the NHL between January 1990 and December 2020 from the NHL-BFM database. Characteristics, therapy, and outcome data were gathered from the database and patient files.
Fifty-seven of 4779 children (1.2%) presented with initial paresis due to spinal cord compression. The median age was 10.3 years (range, 3.1-18.0 years), and 33% were female. Initial symptoms were paresis/weakness (n = 50, 88%), back pain (n = 33, 58%), paresthesia (n = 23, 40%), and bladder dysfunction and/or constipation (n = 22, 39%), persisting for a median of 14 days before diagnosis. Subtype distribution was mature B-NHL (n = 41, 72%), precursor B-lymphoblastic lymphoma (LBL) (n = 12, 21%), anaplastic large cell lymphoma (ALCL) (n = 3, 5%), and T-LBL (n = 1, 2%). Initial emergency therapy included surgery (70%) and/or chemotherapy/steroids (63%). Five-year event-free survival and overall survival (80% ± 5% and 82% ± 5%, respectively) were comparable with all other NHL patients. Neurological symptoms persisted in approximately one-third of surviving patients at the last follow-up.
1.2% of pediatric NHL patients presented with paresis from spinal cord compression mainly due to B-cell lymphomas. Neurological sequelae were observed in one-third of surviving patients.
Mots-clé
Humans, Female, Male, Child, Adolescent, Retrospective Studies, Child, Preschool, Spinal Cord Compression/etiology, Lymphoma, Non-Hodgkin/complications, Lymphoma, Non-Hodgkin/pathology, Lymphoma, Non-Hodgkin/epidemiology, Survival Rate, Prognosis, Follow-Up Studies, back pain, children, non‐Hodgkin Lymphoma, paresis, spinal cord compression
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/07/2024 15:26
Dernière modification de la notice
26/07/2024 6:16
Données d'usage