Endothelin, angiotensin II and adenosine in acute cyclosporine A nephrotoxicity.

Détails

ID Serval
serval:BIB_C25A8B21E7DD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Endothelin, angiotensin II and adenosine in acute cyclosporine A nephrotoxicity.
Périodique
Pediatric Nephrology
Auteur⸱e⸱s
Prévot A., Semama D.S., Tendron A., Justrabo E., Guignard J.P., Gouyon J.B.
ISSN
0931-041X
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
14
Numéro
10-11
Pages
927-934
Langue
anglais
Résumé
We previously developed a model of acute cyclosporine A (CsA)-induced vasomotor nephrotoxicity in rabbits. In the present study, we evaluated the role of endothelin (ET), angiotensin II (AII) and adenosine in this experimental model. All animals received CsA (25 mg/kg/day) for 5 days. Renal function parameters were first measured in a 30-min period, showing renal insufficiency in all animals. Then, rabbits were administered bosentan (10 mg/kg; antagonist of ET(AB) receptors), perindopril (20 microg/kg; angiotensin-converting enzyme inhibitor), or theophylline (1 mg/kg; adenosine receptor blocker at micromolar concentrations). After a 40-min equilibration period, renal function was assessed again for 30 min. Bosentan, perindopril and theophylline significantly reduced renal vascular resistance (-28+/-5%, -39+/-7% and -8+/-3%, respectively), and improved renal blood flow (+38+/-15%, +66+/-16% and +20+/-5%), glomerular filtration rate (+33+/-9%, +52+/-13% and +50+/-8%) and diuresis (+48+/-9%, +76+/-19% and +73+/-14%). Filtration fraction was unchanged with bosentan, decreased with perindopril (-10+/-9%) and increased with theophylline (+24+/-5%). The overall results suggest that ET, AII and adenosine are involved in the acute renal failure induced by CsA. We conclude that CsA administration for 5 days induced a vasomotor nephropathy with ET- and adenosine-mediated afferent arteriolar constriction as well as ET- and AII-mediated efferent arteriolar constriction.
Mots-clé
Acute Disease, Adenosine/pharmacology, Angiotensin II/pharmacology, Angiotensin-Converting Enzyme Inhibitors/pharmacology, Animals, Cyclosporine/blood, Endothelins/pharmacology, Glomerular Filtration Rate/drug effects, Immunosuppressive Agents/blood, Kidney/drug effects, Kidney/pathology, Kidney Diseases/chemically induced, Kidney Diseases/pathology, Male, Perindopril/pharmacology, Rabbits, Renal Circulation/drug effects, Theophylline/pharmacology, Vascular Resistance/drug effects, Water/pharmacology
Pubmed
Création de la notice
20/07/2009 13:33
Dernière modification de la notice
20/08/2019 15:37
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