T cell division and death are segregated by mutation of TCRbeta chain constant domains.

Détails

ID Serval
serval:BIB_C18647EE725B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
T cell division and death are segregated by mutation of TCRbeta chain constant domains.
Périodique
Immunity
Auteur(s)
Teixeiro E., Daniels M.A., Hausmann B., Schrum A.G., Naeher D., Luescher I., Thome M., Bragado R., Palmer E.
ISSN
1074-7613
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
21
Numéro
4
Pages
515-526
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
We have studied the role of the T cell receptor (TCR) beta chain transmembrane and cytoplasmic domains (betaTM/Cyto) in T cell signaling. Upon antigen stimulation, T lymphocytes expressing a TCR with mutant and betaTM and Cyto domains accumulate in large numbers and are specifically defective in undergoing activation-induced cell death (AICD). The mutant TCR poorly recruits the protein adaptor Carma-1 and is subsequently impaired in activating NF-kappaB. This signaling defect leads to a reduced expression of Fas ligand (FasL) and to a reduction in AICD. These beta chain domains are involved in discriminating cell division and apoptosis.
Mots-clé
Amino Acid Sequence, Animals, Antigens, CD, Antigens, Differentiation, T-Lymphocyte, Apoptosis/physiology, Blotting, Western, Cell Division/immunology, Fas Ligand Protein, Flow Cytometry, Interleukin-2/secretion, Lymphocyte Activation/immunology, Membrane Glycoproteins/immunology, Membrane Glycoproteins/metabolism, Mice, Mice, Transgenic, Microscopy, Confocal, Molecular Sequence Data, Mutation, NF-kappa B/immunology, NF-kappa B/metabolism, Protein Structure, Tertiary/genetics, Receptors, Antigen, T-Cell, alpha-beta/genetics, Receptors, Interleukin-2, Signal Transduction/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 11:20
Dernière modification de la notice
20/08/2019 15:36
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