Regional and temporal changes in AIDS in Europe before HAART

Détails

ID Serval
serval:BIB_C158996A56BD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Regional and temporal changes in AIDS in Europe before HAART
Périodique
Epidemiology and Infection
Auteur⸱e⸱s
Blaxhult  A., Fox  Z., Colebunders  R., Francioli  P., Ben-Ishai  Z., Fatkenheuer  G., Parkin  J. M., Vanhems  P., Phillips  A. N., Kirk  O.
ISSN
0950-2688 (Print)
Statut éditorial
Publié
Date de publication
12/2002
Volume
129
Numéro
3
Pages
565-76
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
In a prospective observational study 4,485 patients from 46 clinical centres in 17 European countries were followed between April 1994 and November 1996. Information on AIDS-defining events (ADEs) were collected together with basic demographic data, treatment history and laboratory results. The centres were divided into four geographical regions (north, central, south-west and south-east) so that it was possible to identify any existing regional differences in ADEs. The regional differences that we observed included a higher risk of all forms of Mycobacterium tuberculosis infections (Tb) and wasting disease in the south-west and an increased risk of infections with the Mycobacterium avium complex (MAC) in the north. In Cox multivariable analyses, where north was used as the reference group, we observed hazard ratios of 6.87, 7.77, 2.29 and 0.16 (P < 0.05 in all cases) for pulmonary Tb, extrapulmonary Tb, wasting disease and MAC respectively in the south-west. Pneumocystis carinii pneumonia (PCP) was less commonly diagnosed in the central region (RH = 0.51, 95% CI 0 32-0.79, P = 0.003) and most common in the south-east (RH = 1.04, 95% CI 0.71-1.51, P = 0.85). Comparisons with a similar 'AIDS in Europe' study that concentrated on the early phase of the epidemic reveal that most of the regional differences that were observed in the 1980s still persist in the mid-1990s.
Mots-clé
AIDS-Related Opportunistic Infections/*epidemiology Acquired Immunodeficiency Syndrome/*drug therapy/*epidemiology Adult *Antiretroviral Therapy, Highly Active Epidemiologic Studies Europe/epidemiology Female Humans Incidence Male
Pubmed
Web of science
Création de la notice
25/01/2008 18:07
Dernière modification de la notice
20/08/2019 16:36
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