Sex-related differences in oncologic outcomes, operative complications and health-related quality of life after curative-intent oesophageal cancer treatment: multicentre retrospective analysis.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_C10FEA2032C7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sex-related differences in oncologic outcomes, operative complications and health-related quality of life after curative-intent oesophageal cancer treatment: multicentre retrospective analysis.
Périodique
BJS open
Auteur⸱e⸱s
Mantziari S., Elliott J.A., Markar S.R., Klevebro F., Goense L., Johar A., Lagergren P., Zaninotto G., van Hillegersberg R., van Berge Henegouwen M.I., Schäfer M., Nilsson M., Hanna G.B., Reynolds J.V.
Collaborateur⸱rice⸱s
ENSURE Study Group
Contributeur⸱rice⸱s
Van Veer H., Depypere L., Coosemans W., Nafteux P., Carroll P., Allison F., Darling G., Findlay J.M., Everden S., Maynard N.D., Ariyarathenam A., Sanders G., Jaunoo S., Singh P., Parsons S., Saunders J., Vohra R., Sinha A., Tan BHL, Whiting J.G., Boshier P.R., Markar S.R., Zaninotto G., Hanna G.B., Phillips A.W., Griffin S.M., Walker R.C., Underwood T.J., Piessen G., Theisen J., Friess H., Bruns C.J., Schröder W., Collins C.G., McAnena O.J., Rooney S., Quinn A., Toale C., Murphy T.J., Elliott J.A., Ravi N., Donohoe C.L., Reynolds J.V., Scarpa M., Bardini R., Degasperi S., Saadeh L., Castoro C., Alfieri R., Pinto E., Mattara G., Kalff M.C., Gisbertz S.S., van Berge Henegouwen M.I., van Hootegem SJM, Lagarde S.M., Kingma B.F., Goense L., Ruurda J.P., van Hillegersberg R., Kennedy R., Carey P.D., Prodehl L., Lamb P.J., Skipworth RJE, Cero M.D., Pera M., Huang B., Klevebro F., Nilsson M., Johar A., Lagergren P., Linder G., Sundbom M., Mantziari S., Schäfer M., Demartines N.
ISSN
2474-9842 (Electronic)
ISSN-L
2474-9842
Statut éditorial
Publié
Date de publication
01/03/2024
Peer-reviewed
Oui
Volume
8
Numéro
2
Langue
anglais
Notes
Publication types: Multicenter Study ; Journal Article
Publication Status: ppublish
Résumé
Oesophageal cancer, in particular adenocarcinoma, has a strong male predominance. However, the impact of patient sex on operative and oncologic outcomes and recovery of health-related quality of life is poorly documented, and was the focus of this large multicentre cohort study.
All consecutive patients who underwent oncological oesophagectomy from 2009 to 2015 in the 20 European iNvestigation of SUrveillance after Resection for Esophageal cancer study group centres were assessed. Clinicopathologic variables, therapeutic approach, postoperative complications, survival and health-related quality of life data were compared between male and female patients. Multivariable analyses adjusted for age, sex, tumour histology, treatment protocol and major complications. Specific subgroup analyses comparing adenocarcinoma versus squamous cell cancer for all key outcomes were performed.
Overall, 3974 patients were analysed, 3083 (77.6%) male and 891 (22.4%) female; adenocarcinoma was predominant in both groups, while squamous cell cancer was observed more commonly in female patients (39.8% versus 15.1%, P < 0.001). Multivariable analysis demonstrated improved outcomes in female patients for overall survival (HRmales 1.24, 95% c.i. 1.07 to 1.44) and disease-free survival (HRmales 1.22, 95% c.i. 1.05 to 1.43), which was caused by the adenocarcinoma subgroup, whereas this difference was not confirmed in squamous cell cancer. Male patients presented higher health-related quality of life functional scores but also a higher risk of financial problems, while female patients had lower overall summary scores and more persistent gastrointestinal symptoms.
This study reveals uniquely that female sex is associated with more favourable long-term survival after curative treatment for oesophageal cancer, especially adenocarcinoma, although long-term overall and gastrointestinal health-related quality of life are poorer in women.
Mots-clé
Humans, Male, Female, Quality of Life, Retrospective Studies, Cohort Studies, Esophageal Neoplasms, Carcinoma, Squamous Cell/surgery, Adenocarcinoma
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/04/2024 9:36
Dernière modification de la notice
13/04/2024 6:05
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