The neuroanatomical model of post-stroke depression: towards a change of focus?
Détails
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_C10843BC694D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The neuroanatomical model of post-stroke depression: towards a change of focus?
Périodique
Journal of the neurological sciences
ISSN
1878-5883[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
283
Numéro
1-2
Pages
158-62
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
One third of all stroke survivors develop post-stroke depression (PSD). Depressive symptoms adversely affect rehabilitation and significantly increase risk of death in the post-stroke period. One of the theoretical views on the determinants of PSD focuses on psychosocial factors like disability and social support. Others emphasize biologic mechanisms such as disruption of biogenic amine neurotransmission and release of proinflammatory cytokines. The "lesion location" perspective attempts to establish a relationship between localization of stroke and occurrence of depression, but empirical results remain contradictory. These divergences are partly related to the fact that neuroimaging methods, unlike neuropathology, are not able to assess precisely the full extent of stroke-affected areas and do not specify the different types of vascular lesions. We provide here an overview of the known phenomenological profile and current pathogenic hypotheses of PSD and present neuropathological data challenging the classic "single-stroke"-based neuroanatomical model of PSD. We suggest that vascular burden due to the chronic accumulation of small macrovascular and microvascular lesions may be a crucial determinant of the development and evolution of PSD.
Pubmed
Web of science
Création de la notice
23/07/2009 16:19
Dernière modification de la notice
20/08/2019 16:35