Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.

Détails

ID Serval
serval:BIB_C0FB07A8B571
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Périodique
Cancer cell
Auteur(s)
Dheilly E., Battistello E., Katanayeva N., Sungalee S., Michaux J., Duns G., Wehrle S., Sordet-Dessimoz J., Mina M., Racle J., Farinha P., Coukos G., Gfeller D., Mottok A., Kridel R., Correia B.E., Steidl C., Bassani-Sternberg M., Ciriello G., Zoete V., Oricchio E.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Statut éditorial
Publié
Date de publication
11/05/2020
Peer-reviewed
Oui
Volume
37
Numéro
5
Pages
674-689.e12
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We found that follicular lymphoma patients harbor a recurrent hotspot mutation targeting tyrosine 132 (Y132D) in cathepsin S (CTSS) that enhances protein activity. CTSS regulates antigen processing and CD4 <sup>+</sup> and CD8 <sup>+</sup> T cell-mediated immune responses. Loss of CTSS activity reduces lymphoma growth by limiting communication with CD4 <sup>+</sup> T follicular helper cells while inducing antigen diversification and activation of CD8 <sup>+</sup> T cells. Overall, our results suggest that CTSS inhibition has non-redundant therapeutic potential to enhance anti-tumor immune responses in indolent and aggressive lymphomas.
Mots-clé
T cells, antigen presentation, cysteine proteases, germinal centers, immunotherapy, lymphoma
Pubmed
Web of science
Création de la notice
10/07/2020 14:50
Dernière modification de la notice
18/08/2020 6:26
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