Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_C0C8E88E4752
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations.
Périodique
Regulatory toxicology and pharmacology
Auteur⸱e⸱s
Sanvido O., Basketter D.A., Berthet A., Bloch D., Ezendam J., Hopf N.B., Kleinstreuer N., Merolla L.L., Uter W., Wiemann C., Wilks M.F.
ISSN
1096-0295 (Electronic)
ISSN-L
0273-2300
Statut éditorial
Publié
Date de publication
10/2023
Peer-reviewed
Oui
Volume
144
Pages
105493
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Like many other consumer and occupational products, pesticide formulations may contain active ingredients or co-formulants which have the potential to cause skin sensitisation. Currently, there is little evidence they do, but that could just reflect lack of clinical investigation. Consequently, it is necessary to carry out a safety evaluation process, quantifying risks so that they can be properly managed. A workshop on this topic in 2022 discussed how best to undertake quantitative risk assessment (QRA) for pesticide products, including learning from the experience of industries, notably cosmetics, that already undertake such a process routinely. It also addressed ways to remedy the matter of clinical investigation, even if only to demonstrate the absence of a problem. Workshop participants concluded that QRA for skin sensitisers in pesticide formulations was possible, but required careful justification of any safety factors applied, as well as improvements to the estimation of skin exposure. The need for regulations to stay abreast of the science was also noted. Ultimately, the success of any risk assessment/management for skin sensitisers must be judged by the clinical picture. Accordingly, the workshop participants encouraged the development of more active skin health monitoring amongst groups most exposed to the products.
Mots-clé
Humans, Dermatitis, Allergic Contact/etiology, Pesticides/toxicity, Skin, Risk Assessment, Cosmetics/toxicity, Non-animal methods, Pesticide allergic contact dermatitis, Plant protection products, Quantitative risk assessment, Skin sensitisation
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/09/2023 17:49
Dernière modification de la notice
10/02/2024 8:15
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