Clinical evolution after a non-reactive hypothermic EEG following cardiac arrest.

Détails

Ressource 1Télécharger: BIB_C0A638CD39BF.P001.pdf (462.39 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_C0A638CD39BF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical evolution after a non-reactive hypothermic EEG following cardiac arrest.
Périodique
Neurocritical Care
Auteur(s)
Juan E., Novy J., Suys T., Oddo M., Rossetti A.O.
ISSN
1556-0961 (Electronic)
ISSN-L
1541-6933
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
22
Numéro
3
Pages
403-408
Langue
anglais
Notes
Publication types: Article
Résumé
BACKGROUND: Lack of electroencephalography (EEG) background reactivity during therapeutic hypothermia (TH) has been associated with poor outcome in post-anoxic comatose patients. However, decision on intensive care withdrawal is based on normothermic (NT) evaluations. This study aims at exploring whether patients showing recovery of EEG reactivity in NT after a non-reactive EEG in TH differ from those remaining non-reactive.
METHODS: Patients with non-reactive EEG during TH were identified from our prospective registry of consecutive comatose adults admitted after successful resuscitation from CA between April 2009 and June 2014. Variables including neurological examination, serum neuron-specific enolase (NSE), procalcitonin, and EEG features were compared regarding impact on functional outcome at 3 months.
RESULTS: Seventy-two of 197 patients (37 %) had a non-reactive EEG background during TH with thirteen (18 %) evolving towards reactivity in NT. Compared to those remaining non-reactive (n = 59), they showed significantly better recovery of brainstem reflexes (p < 0.001), better motor responses (p < 0.001), transitory consciousness improvement (p = 0.008), and a tendency toward lower NSE (p = 0.067). One patient recovering EEG reactivity survived with good functional outcome at 3 months.
CONCLUSIONS: Recovery of EEG reactivity from TH to NT seems to distinguish two patients' subgroups regarding early neurological assessment and transitory consciousness improvement, corroborating the role of EEG in providing information about cerebral functions. Understanding these dynamic changes encourages maintenance of intensive support in selected patients even after a non-reactive EEG background in TH, as a small subgroup may indeed recover with good functional outcome.
Mots-clé
Adult, Aged, Aged, 80 and over, Coma/etiology, Coma/physiopathology, Electroencephalography, Female, Heart Arrest/complications, Heart Arrest/physiopathology, Humans, Hypothermia, Induced, Hypoxia-Ischemia, Brain/diagnosis, Hypoxia-Ischemia, Brain/physiopathology, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/12/2014 17:30
Dernière modification de la notice
20/08/2019 16:35
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