Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
Détails
ID Serval
serval:BIB_C0921040B4B8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
Périodique
Genes and Development
ISSN
0890-9369 (Print)
Statut éditorial
Publié
Date de publication
04/2006
Volume
20
Numéro
8
Pages
1028-42
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Apr 15
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Apr 15
Résumé
Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-renewal. Here we show that p63 expression is suppressed by Notch1 activation in both mouse and human keratinocytes through a mechanism independent of cell cycle withdrawal and requiring down-modulation of selected interferon-responsive genes, including IRF7 and/or IRF3. In turn, elevated p63 expression counteracts the ability of Notch1 to restrict growth and promote differentiation. p63 functions as a selective modulator of Notch1-dependent transcription and function, with the Hes-1 gene as one of its direct negative targets. Thus, a complex cross-talk between Notch and p63 is involved in the balance between keratinocyte self-renewal and differentiation.
Mots-clé
Animals
Base Sequence
Cell Differentiation/*physiology
DNA Primers
DNA-Binding Proteins/*physiology
Humans
Keratinocytes/*cytology
Mice
Promoter Regions (Genetics)
RNA, Small Interfering
Receptor, Notch1/*physiology
Trans-Activators/*physiology
Tumor Suppressor Proteins/*physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:59
Dernière modification de la notice
20/08/2019 15:35