Impairment of glucose disposal by infusion of triglycerides in humans: role of glycemia
Détails
ID Serval
serval:BIB_C01F16154D72
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Impairment of glucose disposal by infusion of triglycerides in humans: role of glycemia
Périodique
American Journal of Physiology
ISSN
0002-9513 (Print)
Statut éditorial
Publié
Date de publication
06/1989
Volume
256
Numéro
6 Pt 1
Pages
E747-52
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
The present study was designed to assess the role of hyperglycemia (150 mg/dl) vs. euglycemia (90 mg/dl) on glucose metabolism in vivo during the infusion of a triglyceride emulsion (Intralipid). Seven young healthy volunteers were studied on four occasions using the hyperinsulinemic clamp technique, twice during euglycemia and twice during hyperglycemia, without or with Intralipid. Glucose oxidation (O) was calculated from continuous respiratory exchange measurements, and glucose storage (S) was obtained as the difference between total glucose disposal (M) and O. Two-way analysis of variance with interaction term demonstrated 1) a significant increase for M with hyperglycemia and a decrease with Intralipid; no interaction, and 2) in euglycemia, O/M and S/M occurred in one-to-one ratios; on the other hand, during 150-mg/dl hyperglycemia, the ratio dropped roughly to 1:2. Intralipid had no effect on the ratio, and no interaction could be observed. These results suggest the existence of physiological regulatory mechanisms by which 1) the rise in plasma free fatty acid inhibits both oxidative and nonoxidative glucose disposal, and 2) the rise in glycemia stimulates predominantly nonoxidative glucose disposal.
Mots-clé
Adult
Blood Glucose/*metabolism
Fat Emulsions, Intravenous/*pharmacology
Fatty Acids, Nonesterified/blood
Female
Glucose/*metabolism
Glucose Clamp Technique
Humans
Hyperglycemia/*metabolism
Insulin/blood/pharmacology
Lactates/blood
Male
Reference Values
Somatostatin/pharmacology
Triglycerides/*pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 16:58
Dernière modification de la notice
20/08/2019 16:34