Endoscopic injection of mitomycin adsorbed on carbon particles for advanced esophageal cancer: a pilot study

Détails

ID Serval
serval:BIB_BFFF9925F344
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Endoscopic injection of mitomycin adsorbed on carbon particles for advanced esophageal cancer: a pilot study
Périodique
Endoscopy
Auteur⸱e⸱s
Ortner  M. A., Taha  A. A., Schreiber  S., Wirth  J., Weber-Eibl  J., Ernst  H., Lochs  H.
ISSN
0013-726X (Print)
Statut éditorial
Publié
Date de publication
05/2004
Volume
36
Numéro
5
Pages
421-5
Notes
Clinical Trial
Journal Article --- Old month value: May
Résumé
BACKGROUND AND STUDY AIMS: Patients with advanced, unresectable esophageal carcinoma have an extremely poor prognosis, with dysphagia being the major problem. The aim of this prospective pilot study was to evaluate the efficacy of local injections of mitomycin adsorbed onto activated carbon particles (MMC-CH) in advanced unresectable esophageal squamous-cell carcinoma. The primary outcome parameter was survival time; secondary parameters were dysphagia and quality of life. PATIENTS AND METHODS: Ten consecutive patients with stage IV esophageal carcinoma (age: median 58, range 32 - 78), median tumor length 11 cm (range 5 - 15) received four weekly injections of 15 mg (10 ml) MMC-CH into the endoscopically visualized tumor, via a 5-mm sclerotherapy needle. The tumor stage, symptom score, and quality of life (measured using the Karnofsky index) were assessed before and after therapy and every 2 months thereafter. RESULTS: The median survival time after MMC-CH therapy was 16 weeks (95 % CI, 11.7 to 20.4). Dysphagia was reduced ( P < 0.001) in parallel with the reduction in the tumor mass ( r = 0.82, P = 0.01). The Karnofsky index ( P < 0.01) also improved after MMC-CH treatment. MMC-CH was well tolerated, and no side effects were observed. CONCLUSIONS: Endoluminal MMC-CH therapy appears to be an effective, inexpensive, and well-tolerated treatment for unresectable advanced squamous-cell esophageal carcinoma.
Mots-clé
Adsorption Adult Aged Antibiotics, Antineoplastic/*administration & dosage/pharmacokinetics Carbon/administration & dosage Carcinoma, Squamous Cell/*drug therapy Drug Carriers Endoscopy Esophageal Neoplasms/*drug therapy Female Humans Injections, Intralesional Male Middle Aged Mitomycin/*administration & dosage/pharmacokinetics Pilot Projects
Pubmed
Web of science
Création de la notice
25/01/2008 16:08
Dernière modification de la notice
20/08/2019 15:34
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