Brugada syndrome unmasked by accidental inhalation of gasoline vapors.

Détails

ID Serval
serval:BIB_BFD12F33AAF7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Brugada syndrome unmasked by accidental inhalation of gasoline vapors.
Périodique
Pacing and Clinical Electrophysiology
Auteur⸱e⸱s
Kranjcec D., Bergovec M., Rougier J.S., Raguz M., Pavlovic S., Jespersen T., Castella V., Keller D.I., Abriel H.
ISSN
0147-8389
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
30
Numéro
10
Pages
1294-1298
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline vapors. His electrocardiogram (ECG) showed a typical type-1 BrS pattern that persisted after the acute event. Genetic investigations allowed the identification of a novel SCN5A mutation leading to a frame-shift and early termination of the channel protein. Biochemical and cellular electrophysiology experiments confirmed the loss-of-function of the mutant allele. The patient was implanted with a cardioverter/defibrillator.
Mots-clé
Accidents, Occupational, Atrial Fibrillation/chemically induced, Brugada Syndrome/diagnosis, Brugada Syndrome/genetics, Gasoline/poisoning, Humans, Inhalation, Male, Middle Aged
Pubmed
Web of science
Création de la notice
24/01/2008 10:56
Dernière modification de la notice
20/08/2019 15:34
Données d'usage