The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.

Détails

Ressource 1Télécharger: R31. Rodriguez-Barbosa et al.pdf (1531.99 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_BFABD30627E7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.
Périodique
International journal of molecular sciences
Auteur(s)
Rodriguez-Barbosa J.I., Schneider P., Graca L., Bühler L., Perez-Simon J.A., Del Rio M.L.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Statut éditorial
Publié
Date de publication
09/05/2020
Peer-reviewed
Oui
Volume
21
Numéro
9
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote peripheral Tregs expansion and sustain their survival. This property can be leveraged to enhance tolerance to allogeneic transplants by tipping the balance of Tregs over conventional T cells during the course of immune reconstitution. This is of particular interest in peri-transplant tolerance induction protocols in which T cell depletion is applied to reduce the frequency of alloreactive T cells or in conditioning regimens that allow allogeneic bone marrow transplantation. These conditioning regimens are being implemented to limit long-term side effects of continuous immunosuppression and facilitate the establishment of a state of donor-specific tolerance. Lymphopenia-induced homeostatic proliferation in response to cytoreductive conditioning is a window of opportunity to enhance preferential expansion of Tregs during homeostatic proliferation that can be potentiated by agonist stimulation of TNFR.
Mots-clé
TNF/TNF receptors, graft rejection, graft-versus-host disease, homeostatic proliferation, lymphopenia, regulatory T cells, transplantation
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/06/2020 15:23
Dernière modification de la notice
04/07/2020 7:10
Données d'usage