Superior temporal sulcus anatomical abnormalities in childhood autism: a voxel-based morphometry MRI study.

Détails

ID Serval
serval:BIB_BFA8BBCD84B9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Superior temporal sulcus anatomical abnormalities in childhood autism: a voxel-based morphometry MRI study.
Périodique
Neuroimage
Auteur(s)
Boddaert N., Chabane N., Gervais H., Good C.D., Bourgeois M., Plumet M.H., Barthélémy C., Mouren M.C., Artiges E., Samson Y., Brunelle F., Frackowiak R.S., Zilbovicius M.
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2004
Volume
23
Numéro
1
Pages
364-369
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The underlying neurobiology of autism, a severe pervasive developmental disorder, remains unknown. Few neocortical brain MRI abnormalities have been reported. Using rest functional brain imaging, two independent studies have described localized bilateral temporal hypoperfusion in children with primary autism. In order to search for convergent evidence of anatomical abnormalities in autistic children, we performed an anatomical MRI study using optimized whole-brain voxel-based morphometry (VBM). High-resolution 3-D T1-weighted MRI data sets were acquired in 21 children with primary autism (mean age 9.3 +/- 2.2 years) and 12 healthy control children (mean age 10.8 +/- 2.7 years). By comparing autistic children to normal children, we found bilaterally significant decreases of grey matter concentration located in superior temporal sulcus (STS) (P < 0.05 corrected, after small volume correction; SVC). Children with autism were also found to have a decrease of white matter concentration located in the right temporal pole and in cerebellum (P < 0.05, corrected) compared to normal children. These results suggest that autism is associated with bilateral anatomical abnormalities localized in the STS and are remarkably consistent with functional hypoperfusion previously reported in children with autism. The multimodal STS areas are involved in highest level of cortical integration of both sensory and limbic information. Moreover, the STS is now recognized as a key cortical area of the "social brain" and is implicated in social perceptual skills that are characteristically impaired in autism. Therefore, the convergent anatomical and functional temporal abnormalities observed in autism may be important in the understanding of brain behavior relationships in this severe developmental disorder.
Mots-clé
Adolescent, Atrophy, Autistic Disorder/diagnosis, Autistic Disorder/pathology, Child, Dominance, Cerebral/physiology, Female, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Mathematical Computing, Reference Values, Social Perception, Software, Temporal Lobe/abnormalities, Temporal Lobe/pathology
Pubmed
Web of science
Création de la notice
11/09/2011 18:28
Dernière modification de la notice
20/08/2019 15:34
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