RU 486 inhibits peripheral effects of glucocorticoids in humans
Détails
ID Serval
serval:BIB_BFA7D5EAB022
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
RU 486 inhibits peripheral effects of glucocorticoids in humans
Périodique
Journal of Clinical Endocrinology and Metabolism
ISSN
0021-972X (Print)
Statut éditorial
Publié
Date de publication
12/1985
Volume
61
Numéro
6
Pages
1009-11
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
RU 486 [17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-(prop-1-ynyl)estra-4,9-dien-3-one] is a synthetic steroid receptor antagonist. To evaluate the peripheral antiglucocorticoid action of this compound, we investigated its ability to antagonize cutaneous steroid-induced vasoconstriction. This phenomenon, produced by three different topical steroids in six normal men, was consistently and significantly attenuated or abolished by oral administration of 6 mg/kg RU 486. This demonstration of a peripheral action of RU 486 is important in relation to the potential therapeutic use of this well tolerated drug in states of hypercortisolism. It also indicates that the cutaneous vasoconstrictor effects of topical steroids are mediated by occupancy of glucocorticoid receptors.
Mots-clé
Administration, Topical
Adult
Anti-Inflammatory Agents/*antagonists & inhibitors/pharmacology
Betamethasone/analogs & derivatives/antagonists & inhibitors
Clobetasol/analogs & derivatives/antagonists & inhibitors
Double-Blind Method
Estrenes/*pharmacology
Humans
Hydrocortisone/blood
Male
Mifepristone
Random Allocation
Receptors, Glucocorticoid/physiology
Skin/blood supply
Vasoconstriction/*drug effects
Pubmed
Web of science
Création de la notice
15/02/2008 17:57
Dernière modification de la notice
20/08/2019 16:34