Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_BF74A9FD9308
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.
Périodique
Atherosclerosis
Auteur(s)
Heid I.M., Henneman P., Hicks A., Coassin S., Winkler T., Aulchenko Y.S., Fuchsberger C., Song K., Hivert M.F., Waterworth D.M., Timpson N.J., Richards J.B., Perry J.R., Tanaka T., Amin N., Kollerits B., Pichler I., Oostra B.A., Thorand B., Frants R.R., Illig T., Dupuis J., Glaser B., Spector T., Guralnik J., Egan J.M., Florez J.C., Evans D.M., Soranzo N., Bandinelli S., Carlson O.D., Frayling T.M., Burling K., Smith G.D., Mooser V., Ferrucci L., Meigs J.B., Vollenweider P., Dijk K.W., Pramstaller P., Kronenberg F., van Duijn C.M.
ISSN
1879-1484[electronic]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
208
Numéro
2
Pages
412-420
Langue
anglais
Résumé
OBJECTIVE: Plasma adiponectin is strongly associated with various components of metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are highly heritable and differ between men and women. We therefore aimed to investigate the genetics of plasma adiponectin in men and women. METHODS: We combined genome-wide association scans of three population-based studies including 4659 persons. For the replication stage in 13795 subjects, we selected the 20 top signals of the combined analysis, as well as the 10 top signals with p-values less than 1.0 x 10(-4) for each the men- and the women-specific analyses. We further selected 73 SNPs that were consistently associated with metabolic syndrome parameters in previous genome-wide association studies to check for their association with plasma adiponectin. RESULTS: The ADIPOQ locus showed genome-wide significant p-values in the combined (p=4.3 x 10(-24)) as well as in both women- and men-specific analyses (p=8.7 x 10(-17) and p=2.5 x 10(-11), respectively). None of the other 39 top signal SNPs showed evidence for association in the replication analysis. None of 73 SNPs from metabolic syndrome loci exhibited association with plasma adiponectin (p>0.01). CONCLUSIONS: We demonstrated the ADIPOQ gene as the only major gene for plasma adiponectin, which explains 6.7% of the phenotypic variance. We further found that neither this gene nor any of the metabolic syndrome loci explained the sex differences observed for plasma adiponectin. Larger studies are needed to identify more moderate genetic determinants of plasma adiponectin.
Mots-clé
Colaus Study
Pubmed
Web of science
Création de la notice
16/02/2010 11:28
Dernière modification de la notice
20/08/2019 15:33
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