Implications of chlorhexidine use in burn units for wound healing.

Détails

Ressource 1Télécharger: 2020_Burns.pdf (850.18 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_BF527DF952BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Implications of chlorhexidine use in burn units for wound healing.
Périodique
Burns
Auteur⸱e⸱s
Abdel-Sayed P., Tornay D., Hirt-Burri N., de Buys Roessingh A., Raffoul W., Applegate L.A.
ISSN
1879-1409 (Electronic)
ISSN-L
0305-4179
Statut éditorial
Publié
Date de publication
08/2020
Peer-reviewed
Oui
Volume
46
Numéro
5
Pages
1150-1156
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Chlorhexidine is known to be a potent antiseptic with evidence of a beneficial role in burn care. Nevertheless, several in vitro studies have reported cytotoxicity on cultured cells, while in vivo and clinical data seem to show more controversial results. In the frame of this work, we aimed to evaluate the use of chlorhexidine in burn units worldwide be sending a survey to professionals of the field. We associated survey results to those perspectives reported in the literature to update recommendations for the use of chlorhexidine in specific protocols for burn management. The survey results showed that there is no clear consensus on the use of chlorhexidine regarding the concentrations, the type of excipient and the cleansing after application. Literature searches showed evidence that the skin of premature infants appears to be more sensitive to chlorhexidine that adult skin, with more reported cases of adverse effects. It was also determined that aqueous formulations of chlorhexidine do not appear to be necessarily less efficient than with alcohol as an excipient, and that lower concentrations are as efficient as higher concentrations. In view of this study, we have adjusted our protocols for the use of aqueous formulations at low concentrations and investigated further the role of washing after application in order to standardize the indication of chlorhexidine and minimize the probability of adverse effects.
Mots-clé
Surgery, Critical Care and Intensive Care Medicine, Emergency Medicine, General Medicine, Burns, Chlorhexidine, Cytotoxicity, Wound healing
Pubmed
Web of science
Open Access
Oui
Financement(s)
Commission Européenne / H2020 / 833594
Création de la notice
10/01/2020 12:44
Dernière modification de la notice
19/06/2021 6:33
Données d'usage