The inflammasome: a danger sensing complex triggering innate immunity.

Détails

ID Serval
serval:BIB_BF47A689940D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The inflammasome: a danger sensing complex triggering innate immunity.
Périodique
Current Opinion in Immunology
Auteur⸱e⸱s
Pétrilli V., Dostert C., Muruve D.A., Tschopp J.
ISSN
0952-7915 (Print)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
2007
Volume
19
Numéro
6
Pages
615-622
Langue
anglais
Résumé
The NOD-like receptors (NLR) are a family of intracellular sensors of microbial motifs and 'danger signals' that have emerged as being crucial components of the innate immune responses and inflammation. Several NLRs (NALPs and IPAF) form a caspase-1-activating multiprotein complex, termed inflammasome, that processes proinflammatory cytokines including IL-1beta. Amongst the various inflammasomes, the NALP3 inflammasome is particularly qualified to sense a plethora of diverse molecules, ranging from bacterial muramyldipeptide to monosodium urate crystals. The important role of the NALP3 inflammasome is emphasized by the identification of mutations in the NALP3 gene that are associated with a susceptibility to inflammatory disorders. These and other issues related to the inflammasome are discussed in this review.
Mots-clé
Animals, Antigens, Bacterial/immunology, Carrier Proteins/immunology, Carrier Proteins/metabolism, Caspases/metabolism, Cytokines/immunology, Cytokines/metabolism, Humans, Immunity, Innate, Inflammation Mediators/immunology, Inflammation Mediators/metabolism, Receptors, Pattern Recognition/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:19
Dernière modification de la notice
20/08/2019 15:33
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