Integrating evolutionary and molecular genetics of aging

Détails

ID Serval
serval:BIB_BEDAABB522D3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Integrating evolutionary and molecular genetics of aging
Périodique
Biochimica et Biophysica Acta (BBA) - General Subjects
Auteur⸱e⸱s
Flatt Thomas, Schmidt Paul S.
ISSN
0304-4165
ISSN-L
1872-8006
Statut éditorial
Publié
Date de publication
10/2009
Peer-reviewed
Oui
Volume
1790
Numéro
10
Pages
951-962
Langue
anglais
Résumé
Aging or senescence is an age-dependent decline in physiological function, demographically manifest as decreased survival and fecundity with increasing age. Since aging is disadvantageous it should not evolve by natural selection. So why do organisms age and die? In the 1940s and 1950s evolutionary geneticists resolved this paradox by positing that aging evolves because selection is inefficient at maintaining function late in life. By the 1980s and 1990s this evolutionary theory of aging had received firm empirical support, but little was known about the mechanisms of aging. Around the same time biologists began to apply the tools of molecular genetics to aging and successfully identified mutations that affect longevity. Today, the molecular genetics of aging is a burgeoning field, but progress in evolutionary genetics of aging has largely stalled. Here we argue that some of the most exciting and unresolved questions about aging require an integration of molecular and evolutionary approaches. Is aging a universal process? Why do species age at different rates? Are the mechanisms of aging conserved or lineage-specific? Are longevity genes identified in the laboratory under selection in natural populations? What is the genetic basis of plasticity in aging in response to environmental cues and is this plasticity adaptive? What are the mechanisms underlying trade-offs between early fitness traits and life span? To answer these questions evolutionary biologists must adopt the tools of molecular biology, while molecular biologists must put their experiments into an evolutionary framework. The time is ripe for a synthesis of molecular biogerontology and the evolutionary biology of aging.
Mots-clé
Aging/genetics, Animals, Evolution, Molecular, Genetics, Population, Genotype, Humans, Longevity/genetics, Phenotype, Quantitative Trait Loci/genetics, Selection, Genetic
Pubmed
Web of science
Création de la notice
28/01/2013 13:07
Dernière modification de la notice
20/08/2019 16:33
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