Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

Détails

ID Serval
serval:BIB_BEBA1C67CD92
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
Périodique
Nature Genetics
Auteur⸱e⸱s
Scott R.A., Lagou V., Welch R.P., Wheeler E., Montasser M.E., Luan J., Mägi R., Strawbridge R.J., Rehnberg E., Gustafsson S., Kanoni S., Rasmussen-Torvik L.J., Yengo L., Lecoeur C., Shungin D., Sanna S., Sidore C., Johnson P.C., Jukema J.W., Johnson T., Mahajan A., Verweij N., Thorleifsson G., Hottenga J.J., Shah S., Smith A.V., Sennblad B., Gieger C., Salo P., Perola M., Timpson N.J., Evans D.M., Pourcain B.S., Wu Y., Andrews J.S., Hui J., Bielak L.F., Zhao W., Horikoshi M., Navarro P., Isaacs A., O'Connell J.R., Stirrups K., Vitart V., Hayward C., Esko T., Mihailov E., Fraser R.M., Fall T., Voight B.F., Raychaudhuri S., Chen H., Lindgren C.M., Morris A.P., Rayner N.W., Robertson N., Rybin D., Liu C.T., Beckmann J.S., Willems S.M., Chines P.S., Jackson A.U., Kang H.M., Stringham H.M., Song K., Tanaka T., Peden J.F., Goel A., Hicks A.A., An P., Müller-Nurasyid M., Franco-Cereceda A., Folkersen L., Marullo L., Jansen H., Oldehinkel A.J., Bruinenberg M., Pankow J.S., North K.E., Forouhi N.G., Loos R.J., Edkins S., Varga T.V., Hallmans G., Oksa H., Antonella M., Nagaraja R., Trompet S., Ford I., Bakker S.J., Kong A., Kumari M., Gigante B., Herder C., Munroe P.B., Caulfield M., Antti J., Mangino M., Small K., Miljkovic I., Liu Y., Atalay M., Kiess W., James A.L., Rivadeneira F., Uitterlinden A.G., Palmer C.N., Doney A.S., Willemsen G., Smit J.H., Campbell S., Polasek O., Bonnycastle L.L., Hercberg S., Dimitriou M., Bolton J.L., Fowkes G.R., Kovacs P., Lindström J., Zemunik T., Bandinelli S., Wild S.H., Basart H.V., Rathmann W., Grallert H., Maerz W., Maerz W., Kleber M.E., Boehm B.O., Peters A., Pramstaller P.P., Province M.A., Borecki I.B., Hastie N.D., Rudan I., Campbell H., Watkins H., Farrall M., Stumvoll M., Ferrucci L., Waterworth D.M., Bergman R.N., Collins F.S., Tuomilehto J., Watanabe R.M., de Geus E.J., Penninx B.W., Hofman A., Oostra B.A., Psaty B.M., Vollenweider P., Wilson J.F., Wright A.F., Hovingh G.K., Metspalu A., Uusitupa M., Magnusson P.K., Kyvik K.O., Kaprio J., Price J.F., Dedoussis G.V., Deloukas P., Meneton P., Lind L., Boehnke M., Shuldiner A.R., van Duijn C.M., Morris A.D., Toenjes A., Peyser P.A., Beilby J.P., Körner A., Kuusisto J., Laakso M., Bornstein S.R., Schwarz P.E., Lakka T.A., Rauramaa R., Adair L.S., Smith G.D., Spector T.D., Illig T., de Faire U., Hamsten A., Gudnason V., Kivimaki M., Hingorani A., Keinanen-Kiukaanniemi S.M., Saaristo T.E., Boomsma D.I., Stefansson K., van der Harst P., Dupuis J., Pedersen N.L., Sattar N., Harris T.B., Cucca F., Ripatti S., Salomaa V., Mohlke K.L., Balkau B., Froguel P., Pouta A., Jarvelin M.R., Wareham N.J., Bouatia-Naji N., McCarthy M.I., Franks P.W., Meigs J.B., Teslovich T.M., Florez J.C., Langenberg C., Ingelsson E., Prokopenko I., Barroso I.
Collaborateur⸱rice⸱s
DIAbetes Genetics Replication, Meta-analysis (DIAGRAM) Consortium
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Statut éditorial
Publié
Date de publication
2012
Volume
44
Numéro
9
Pages
991-1005
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. Publication Status: ppublish. PDF type: article
Résumé
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.
Mots-clé
Adult, Animals, Blood Glucose/genetics, Blood Glucose/metabolism, Fasting/blood, Fasting/metabolism, Female, Gene Frequency, Genome-Wide Association Study/statistics & numerical data, Humans, Insulin/blood, Male, Metabolic Networks and Pathways/genetics, Mice, Osmolar Concentration, Quantitative Trait Loci/physiology
Pubmed
Web of science
Création de la notice
10/01/2013 11:49
Dernière modification de la notice
20/08/2019 15:33
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