Telomere dynamics rather than age predict life expectancy in the wild.

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_BE524B818E2D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Telomere dynamics rather than age predict life expectancy in the wild.
Périodique
Proceedings. Biological sciences / The Royal Society
Auteur(s)
Bize P., Criscuolo F., Metcalfe N.B., Nasir L., Monaghan P.
ISSN
0962-8452
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
276
Numéro
1662
Pages
1679-83
Langue
anglais
Résumé
Despite accumulating evidence from in vitro studies that cellular senescence is linked to telomere dynamics, how this relates to whole-organism senescence and longevity is poorly understood and controversial. Using data on telomere length in red blood cells and long-term survival from wild Alpine swifts of a range of ages, we report that the telomere length and the rate of telomere loss are predictive of life expectancy, and that slow erosion of relatively long telomeres is associated with the highest survival probabilities. Importantly, because telomere dynamics, rather than chronological age, predict life expectancy, our study provides good evidence for a mechanistic link between telomere erosion and reduced organism longevity under natural conditions, chronological age itself possibly not becoming a significant predictor until very old ages beyond those in our sample.
Pubmed
Web of science
Création de la notice
22/01/2009 11:49
Dernière modification de la notice
20/08/2019 16:32
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