Blood rheology in acute mountain sickness and high-altitude pulmonary edema.

Détails

ID Serval
serval:BIB_BE461C48D93B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Blood rheology in acute mountain sickness and high-altitude pulmonary edema.
Périodique
Journal of Applied Physiology
Auteur⸱e⸱s
Reinhart W.H., Kayser B., Singh A., Waber U., Oelz O., Bärtsch P.
ISSN
8750-7587 (Print)
ISSN-L
0161-7567
Statut éditorial
Publié
Date de publication
1991
Volume
71
Numéro
3
Pages
934-938
Langue
anglais
Résumé
The role of blood rheology in the pathogenesis of acute mountain sickness and high-altitude pulmonary edema was investigated. Twenty-three volunteers, 12 with a history of high-altitude pulmonary edema, were studied at low altitude (490 m) and at 2 h and 18 h after arrival at 4,559 m. Eight subjects remained healthy, seven developed acute mountain sickness, and eight developed high-altitude pulmonary edema. Hematocrit, whole blood viscosity, plasma viscosity, erythrocyte aggregation, and erythrocyte deformability (filtration) were measured. Plasma viscosity and erythrocyte deformability remained unaffected. The hematocrit level was lower 2 h after the arrival at high altitude and higher after 18 h compared with low altitude. The whole blood viscosity changed accordingly. The erythrocyte aggregation was about doubled 18 h after the arrival compared with low-altitude values, which reflects the acute phase reaction. There were, however, no significant differences in any rheological parameters between healthy individuals and subjects with acute mountain sickness or high-altitude pulmonary edema, either before or during the illness. We conclude that rheological abnormalities can be excluded as an initiating event in the development of acute mountain sickness and high-altitude pulmonary edema.
Mots-clé
Acute Disease, Adult, Altitude Sickness/complications, Altitude Sickness/drug therapy, Blood Flow Velocity/drug effects, Blood Viscosity/drug effects, Blood Viscosity/physiology, Erythrocyte Aggregation/drug effects, Erythrocyte Aggregation/physiology, Erythrocyte Deformability/drug effects, Erythrocyte Deformability/physiology, Hematocrit, Humans, Male, Middle Aged, Nifedipine/therapeutic use, Oxygen/blood, Pulmonary Edema/etiology, Pulmonary Edema/physiopathology, Rheology
Pubmed
Web of science
Création de la notice
19/09/2013 11:33
Dernière modification de la notice
20/08/2019 16:32
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