Long-term pulmonary sequelae after autologous bone marrow transplantation in children without total body irradiation

Détails

ID Serval
serval:BIB_BE4443DA8FCE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Long-term pulmonary sequelae after autologous bone marrow transplantation in children without total body irradiation
Périodique
Bone Marrow Transplantation
Auteur(s)
Nenadov Beck  M., Meresse  V., Hartmann  O., Gaultier  C.
ISSN
0268-3369
Statut éditorial
Publié
Date de publication
12/1995
Peer-reviewed
Oui
Volume
16
Numéro
6
Pages
771-5
Notes
Journal Article --- Old month value: Dec
Résumé
We investigated the long-term pulmonary sequelae of 38 children surviving 3 to 11.5 years (median 7 years) after high-dose chemotherapy (HDC) and autologous bone marrow transplantation (ABMT) without TBI. This cross-sectional study included patients with neuroblastoma (21), non-Hodgkin's lymphoma (7), Ewing's sarcoma (5), rhabdomyosarcoma (3), medulloblastoma (1) and ALL (1). They were asked and examined for clinical signs and underwent a physical examination with chest X-ray; 33/38 had pulmonary function tests (PFT) performed. No obstructive disease was found. Fifteen out of 32 evaluable PFT (47%) were abnormal with a pulmonary restrictive syndrome in 10, and borderline values in five patients. Four of these 15 patients were symptomatic with exertional dyspnea and two of four had abnormal chest X-rays. The etiology was mainly multifactorial, associating HDC with thoracic radiotherapy +/- scoliosis/kyphosis +/- previous thoracotomy +/- post-ABMT interstitial pneumonitis. Only 3/10 patients with a restrictive syndrome had HDC containing BCNU or busulfan as the only risk factor for lung disease. We conclude that the prevalence of late pulmonary sequelae after ABMT without TBI is moderate and rarely due to HDC alone, since most abnormal PFT can be explained by heavy pretreatment prior to ABMT. As symptoms are scarce even in advanced disease, repeated testing and very long-term follow-up are needed.
Mots-clé
Adolescent Adult Antineoplastic Agents/adverse effects Bone Marrow Transplantation/*adverse effects Child Child, Preschool Female Humans Lung Diseases/*etiology/physiopathology Male Neoplasms/therapy Risk Factors Time Factors Transplantation, Autologous Whole-Body Irradiation
Pubmed
Création de la notice
20/03/2008 9:34
Dernière modification de la notice
20/08/2019 15:32
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