Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.

Détails

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Etat: Public
Version: de l'auteur⸱e
Licence: CC BY 4.0
ID Serval
serval:BIB_BE26AADAD401
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.
Périodique
PloS one
Auteur⸱e⸱s
Regina J., Papadimitriou-Olivgeris M., Burger R., Le Pogam M.A., Niemi T., Filippidis P., Tschopp J., Desgranges F., Viala B., Kampouri E., Rochat L., Haefliger D., Belkoniene M., Fidalgo C., Kritikos A., Jaton K., Senn L., Bart P.A., Pagani J.L., Manuel O., Lhopitallier L.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
15
Numéro
11
Pages
e0240781
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: epublish
Résumé
This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.
This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.
145 patients were included in the multivariate model, of whom 36 (24.8%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation with age (OR 1.09 per year, 95% CI 1.03-1.16, p = 0.002), in males (OR 6.99, 95% CI 1.68-29.03, p = 0.007), in patients who presented with a qSOFA score ≥2 (OR 7.24, 95% CI 1.64-32.03, p = 0.009), with bilateral infiltrate (OR 18.92, 3.94-98.23, p<0.001) or with a CRP of 40 mg/l or greater (OR 5.44, 1.18-25.25; p = 0.030) on admission. Patients with more than seven days of symptoms on admission had decreased odds of mechanical ventilation (0.087, 95% CI 0.02-0.38, p = 0.001).
This study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Age, male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Betacoronavirus, COVID-19, Coronavirus Infections/epidemiology, Electronic Health Records, Female, Hospitalization, Hospitals, University, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Pandemics, Pneumonia, Viral/epidemiology, Respiration, Artificial/statistics & numerical data, Retrospective Studies, Risk Factors, SARS-CoV-2, Switzerland, Tertiary Care Centers, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/11/2020 15:56
Dernière modification de la notice
15/01/2024 17:16
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