REM sleep stabilizes hypothalamic representation of feeding behavior

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Ressource 1Télécharger: REMsleepFeeding_PNAS.pdf (6177.71 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_BE018CD2E04E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
REM sleep stabilizes hypothalamic representation of feeding behavior
Périodique
Proceedings of the National Academy of Sciences
Auteur⸱e⸱s
Oesch Lukas, Mary Gazea, Gent Thomas, Bandarabadi Mojtaba, Carolina Gutierrez Herrera, Adamantidis Antoine
Statut éditorial
Publié
Date de publication
11/08/2020
Langue
anglais
Résumé
During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LHvgat) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LHvgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior.
Création de la notice
06/07/2021 14:28
Dernière modification de la notice
07/07/2021 6:12
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