Aging adults and seasonal influenza: does the vitamin d status (h)arm the body?
Détails
ID Serval
serval:BIB_BDDF83D2B7B3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Aging adults and seasonal influenza: does the vitamin d status (h)arm the body?
Périodique
Journal of Aging Research
ISSN
2090-2212 (Electronic)
ISSN-L
2090-2204
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
2012
Pages
806198
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Vitamin D (VitD), although originally described as an essential hormone for bone and mineral homeostasis, appears to have an active role in regulating specific facets of human immunity. Indeed, VitD has been shown to have significant effects on cytokine production and lymphocyte proliferation. Evidence that VitD affects clearance of selected pathogens is supported by epidemiological and clinical data, while its coadministration with influenza vaccine in mice enhanced both mucosal and systemic antibody responses. This paper aims to examine how VitD may contribute to limiting the burden of influenza infection in the aging and aged adults, a population in which this burden remains considerable. Furthermore, we discuss how VitD status may play a role in host resistance to influenza virus and influence the immunogenicity of the influenza vaccines currently licensed for adults aged 65 years or over by its effects on innate and adaptive immunities.
Pubmed
Open Access
Oui
Création de la notice
15/04/2015 10:26
Dernière modification de la notice
20/08/2019 16:32