The cerebral metabolism of glucose and oxygen measured with positron tomography in patients with mitochondrial diseases.

Détails

ID Serval
serval:BIB_BDCB614F8770
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
The cerebral metabolism of glucose and oxygen measured with positron tomography in patients with mitochondrial diseases.
Périodique
Brain
Auteur(s)
Frackowiak R.S., Herold S., Petty R.K., Morgan-Hughes J.A.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
1988
Volume
111 ( Pt 5)
Pages
1009-1024
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Cerebral oxygen and glucose metabolism have been studied in 8 patients with biochemically defined mitochondrial myopathies and 7 normal control subjects using positron emission tomography. Four patients had myopathy alone and 4 had predominantly central nervous system (CNS) disease. Cerebral oxygen and glucose metabolism were measured concurrently in the two groups of patients with 15O, 11C and 18F labelled tracers and positron emission tomography (PET). Patients with major CNS disease showed an uncoupling of glucose and oxygen metabolism when compared with patients without cerebral disease and normal subjects. The mean ratio between oxygen and glucose utilization was 3.8 moles of oxygen per mole of glucose in patients with CNS disease, compared with 5.6 for controls and 6.4 for patients with myopathy alone. The altered stoichiometry in CNS cases indicates aerobic glycolysis to lactate and/or other intermediate metabolites. Patients with major CNS disease showed a 50% reduction in cerebral oxygen utilization compared with cerebrally unaffected patients and normal subjects. These findings indicate that in patients with a mitochondrial encephalopathy the defect identified in skeletal muscle is also expressed in the brain.
Mots-clé
Adult, Brain/metabolism, Brain/radionuclide imaging, Brain Diseases/complications, Central Nervous System Diseases/complications, Central Nervous System Diseases/metabolism, Deoxyglucose/analogs & derivatives, Deoxyglucose/diagnostic use, Female, Fluorodeoxyglucose F18, Glucose/metabolism, Humans, Male, Metabolism, Inborn Errors/complications, Metabolism, Inborn Errors/metabolism, Middle Aged, Mitochondria, Muscle/metabolism, Oxygen Consumption, Reference Values, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
08/10/2011 14:17
Dernière modification de la notice
20/08/2019 15:32
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