Diversification of human plasmacytoid predendritic cells in response to a single stimulus.

Détails

ID Serval
serval:BIB_BDC98A31CFA1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Diversification of human plasmacytoid predendritic cells in response to a single stimulus.
Périodique
Nature immunology
Auteur(s)
Alculumbre S.G., Saint-André V., Di Domizio J., Vargas P., Sirven P., Bost P., Maurin M., Maiuri P., Wery M., Roman M.S., Savey L., Touzot M., Terrier B., Saadoun D., Conrad C., Gilliet M., Morillon A., Soumelis V.
ISSN
1529-2916 (Electronic)
ISSN-L
1529-2908
Statut éditorial
Publié
Date de publication
01/2018
Peer-reviewed
Oui
Volume
19
Numéro
1
Pages
63-75
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1+CD80-) displayed a plasmacytoid morphology and specialization for type I interferon production. P3-pDCs (PD-L1-CD80+) adopted a dendritic morphology and adaptive immune functions. P2-pDCs (PD-L1+CD80+) displayed both innate and adaptive functions. Each subpopulation expressed a specific coding- and long-noncoding-RNA signature and was stable after secondary stimulation. P1-pDCs were detected in samples from patients with lupus or psoriasis. pDC diversification was independent of cell divisions or preexisting heterogeneity within steady-state pDCs but was controlled by a TNF autocrine and/or paracrine communication loop. Our findings reveal a novel mechanism for diversity and division of labor in innate immune cells.

Mots-clé
Adaptive Immunity/immunology, B7-1 Antigen/immunology, B7-1 Antigen/metabolism, B7-H1 Antigen/immunology, B7-H1 Antigen/metabolism, Cells, Cultured, Cytokines/genetics, Cytokines/immunology, Cytokines/metabolism, Dendritic Cells/immunology, Dendritic Cells/metabolism, Dendritic Cells/ultrastructure, Gene Expression/immunology, Gene Expression Profiling/methods, Humans, Immunity, Innate/immunology, Interferon Type I/genetics, Interferon Type I/immunology, Interferon Type I/metabolism, Lupus Erythematosus, Systemic/immunology, Microscopy, Electron, Transmission, Orthomyxoviridae/immunology, Psoriasis/immunology
Pubmed
Web of science
Création de la notice
13/01/2018 13:21
Dernière modification de la notice
20/08/2019 15:32
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