Associations of duration of untreated psychosis (DUP) and outcome in an epidemiological sample of 668 patients with first-episode psychosis

Détails

ID Serval
serval:BIB_BDA9CE17FAC0
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Associations of duration of untreated psychosis (DUP) and outcome in an epidemiological sample of 668 patients with first-episode psychosis
Auteur⸱e⸱s
Huber C.G., Graf Schimmelmann Benno, Conus Philippe, Naber Dieter, McGorry Patrick D., Lambert Martin
ISBN
0920-9964
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
81
Série
Schizophrenia Research
Pages
237-238
Langue
anglais
Notes
SAPHIRID:62927
Résumé
Background: There is convincing evidence that DUP is associated with poor outcome. However, despite the knowledge that study refusers have significantly longer DUP than consenters, none of the previous studies assessed an epidemiological sample without informed consent bias.
Methods: 786 first-episode psychosis (FEP) patients were admitted to EPPIC between 1998-2000. Data were collected from medical records of 668 patients meeting inclusion criteria. DUP was categorized into V4, 5-12, 13-52 and >52 weeks. Cox-regression was used to predict remission of positive symptoms (remission) and vocational status (vocation).
Results: Median DUP was 11.8 weeks (0-732); a DUP longer than 3 months (with DUP V4 weeks as reference category) was negatively related to remission (Hazard Ratio (HR)=0.54; CI=0.400.72) and to vocation (HR=0.54; CI=0.390.75) when controlled for gender, age at DUP started, and pre-morbid functioning. Besides DUP, remission was further predicted by better pre-morbid functioning (HR=1.01), older age at start of DUP (HR=1.04), and a lower CGI-S at baseline (HR=0.81). A positive vocation at followup was predicted by better pre-morbid functioning (HR=1.02) and a positive vocation at baseline (HR=1.61).
Conclusions: These findings from a sample without informed consent bias underline the importance of DUP as an independent variable predicting remission and vocation in FEP.
Création de la notice
10/03/2008 9:59
Dernière modification de la notice
20/08/2019 15:31
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