Erythropoietin abuse and erythropoietin gene doping: detection strategies in the genomic era.

Détails

ID Serval
serval:BIB_BDA9CB8F03F9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Erythropoietin abuse and erythropoietin gene doping: detection strategies in the genomic era.
Périodique
Sports Medicine
Auteur⸱e⸱s
Diamanti-Kandarakis E., Konstantinopoulos P.A., Papailiou J., Kandarakis S.A., Andreopoulos A., Sykiotis G.P.
ISSN
0112-1642 (Print)
ISSN-L
0112-1642
Statut éditorial
Publié
Date de publication
2005
Volume
35
Numéro
10
Pages
831-840
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
The administration of recombinant human erythropoietin (rhEPO) increases the maximum oxygen consumption capacity, and is therefore abused as a doping method in endurance sports. The detection of erythropoietin (EPO) abuse is based on direct pharmacological and indirect haematological approaches, both of which have several limitations. In addition, current detection methods cannot cope with the emerging doping strategies of EPO mimicry, analogues and gene doping, and thus novel detection strategies are urgently needed. Direct detection methods for EPO misuse can be either pharmacological approaches that identify exogenous substances based on their physicochemical properties, or molecular methods that recognise EPO transgenes or gene transfer vectors. Since direct detection with molecular methods requires invasive procedures, it is not appropriate for routine screening of large numbers of athletes. In contrast, novel indirect methods based on haematological and/or molecular profiling could be better suited as screening tools, and athletes who are suspect of doping would then be submitted to direct pharmacological and molecular tests. This article reviews the current state of the EPO doping field, discusses available detection methods and their shortcomings, outlines emerging pharmaceutical and genetic technologies in EPO misuse, and proposes potential directions for the development of novel detection strategies.
Mots-clé
Doping in Sports, Erythropoietin/administration & dosage, Erythropoietin/genetics, Genomics, Humans, Substance Abuse Detection/methods, Substance-Related Disorders/diagnosis
Pubmed
Web of science
Création de la notice
20/01/2015 14:50
Dernière modification de la notice
20/08/2019 16:31
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