An evaluation of irreversible electroporation thresholds in human prostate cancer and potential correlations to physiological measurements.

Détails

Ressource 1Télécharger: 31069281_BIB_BDA6220A2F72.pdf (1805.02 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_BDA6220A2F72
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
An evaluation of irreversible electroporation thresholds in human prostate cancer and potential correlations to physiological measurements.
Périodique
APL bioengineering
Auteur⸱e⸱s
Campelo S., Valerio M., Ahmed H.U., Hu Y., Arena S.L., Neal R.E., Emberton M., Arena C.B.
ISSN
2473-2877 (Electronic)
ISSN-L
2473-2877
Statut éditorial
Publié
Date de publication
12/2017
Peer-reviewed
Oui
Volume
1
Numéro
1
Pages
016101
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Irreversible electroporation (IRE) is an emerging cancer treatment that utilizes non-thermal electric pulses for tumor ablation. The pulses are delivered through minimally invasive needle electrodes inserted into the target tissue and lead to cell death through the creation of nanoscale membrane defects. IRE has been shown to be safe and effective when performed on tumors in the brain, liver, kidneys, pancreas, and prostate that are located near critical blood vessels and nerves. Accurate treatment planning and prediction of the ablation volume require a priori knowledge of the tissue-specific electric field threshold for cell death. This study addresses the challenge of defining an electric field threshold for human prostate cancer tissue. Three-dimensional reconstructions of the ablation volumes were created from one week post-treatment magnetic resonance imaging (MRIs) of ten patients who completed a clinical trial. The ablation volumes were incorporated into a finite element modeling software that was used to simulate patient-specific treatments, and the electric field threshold was calculated by matching the ablation volume to the field contour encompassing the equivalent volume. Solutions were obtained for static tissue electrical properties and dynamic properties that accounted for electroporation. According to the dynamic model, the electric field threshold was 506 ± 66 V/cm. Additionally, a potentially strong correlation (r = -0.624) was discovered between the electric field threshold and pre-treatment prostate-specific antigen levels, which needs to be validated in higher enrollment studies. Taken together, these findings can be used to guide the development of future IRE protocols.
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/09/2020 16:48
Dernière modification de la notice
15/01/2021 7:11
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