Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.

Détails

Ressource 1Télécharger: BIB_BD9B25FFCA7D.P001.pdf (229.81 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_BD9B25FFCA7D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
Périodique
Plos One
Auteur(s)
Essig S., von der Weid N.X., Strippoli M.P., Rebholz C.E., Michel G., Rueegg C.S., Niggli F.K., Kuehni C.E.
Collaborateur(s)
Swiss Pediatric Oncology Group (SPOG)
Contributeur(s)
Ammann R., Angst R., Beck Popovic M., Brazzola P., Greiner J., Hengartner H., Kuehne T., Leibundgut K., Niggli F., Nobile Buetti L., Ozsahin A., Rischewski J., Grotzer M., von der Weid N.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2012
Volume
7
Numéro
5
Pages
e38015
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely unmeasured. Our aim was to compare HRQOL of ALL survivors with the general population, and of relapsed with non-relapsed ALL survivors.
METHODOLOGY/PRINCIPAL FINDINGS: As part of the Swiss Childhood Cancer Survivor Study (SCCSS) we sent a questionnaire to all ALL survivors in Switzerland who had been diagnosed between 1976-2003 at age <16 years, survived ≥5 years, and were currently aged ≥16 years. HRQOL was assessed with the Short Form-36 (SF-36), which measures four aspects of physical health and four aspects of mental health. A score of 50 corresponded to the mean of a healthy reference population. We analyzed data from 457 ALL survivors (response: 79%). Sixty-one survivors had suffered a relapse. Compared to the general population, ALL survivors reported similar or higher HRQOL scores on all scales. Survivors with a relapse scored lower in general health perceptions (51.6) compared to those without (55.8;p=0.005), but after adjusting for self-reported late effects, this difference disappeared.
CONCLUSION/SIGNIFICANCE: Compared to population norms, ALL survivors reported good HRQOL, even after a relapse. However, relapsed ALL survivors reported poorer general health than non-relapsed. Therefore, we encourage specialists to screen for poor general health in survivors after a relapse and, when appropriate, specifically seek and treat underlying late effects. This will help to improve patients' HRQOL.
Mots-clé
Adolescent, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Precursor Cell Lymphoblastic Leukemia-Lymphoma/psychology, Quality of Life, Questionnaires, Recurrence, Survivors/psychology, Switzerland
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/07/2012 9:50
Dernière modification de la notice
27/09/2019 8:05
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