Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered.

Détails

ID Serval
serval:BIB_BD9836E284EB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered.
Périodique
European Journal of Immunology
Auteur(s)
Bachmann M.F., Gallimore A., Jones E., Ecabert B., Acha-Orbea H., Kopf M.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
31
Numéro
2
Pages
450-458
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
CTLA-4 is a critical negative regulator of T cell responses and CTLA-4-deficient (CTLA-4(-/-)) mice die of a lymphproliferative disease. Nevertheless, RAG-2-deficient mice reconstituted with a mixture of CTLA-4(-/-) and normal (CTLA-4(+/+)) bone marrow survive in the absence of any signs of disease, although 50% of their T cells do not express CTLA-4. Using such mixed chimeras, we analyzed the role of CTLA-4 in specific T cell responses to lymphocytic choriomeningitis virus, Leishmania major and mouse mammary tumor virus, which cause acute, chronic and persistent infections, respectively. The populations of antigen-specific CTLA-4(-/-)CD4(+) and CTLA-4(-/-)CD8(+) T cells became activated, expanded and contracted indistinguishably from CTLA-4(+/+)CD4(+) and CTLA-4(+/+)CD8(+) T cells after infection with all three pathogens. Thus, CTLA-4 is not involved in the down-regulation of specific T cell responses and peripheral deletion in a T cell-autonomous fashion.
Mots-clé
Animals, Antigens, CD, Antigens, Differentiation/physiology, CTLA-4 Antigen, Chimera, Cytokines/biosynthesis, Immunoconjugates, Leishmania major/immunology, Lymphocyte Count, Lymphocytic choriomeningitis virus/immunology, Mammary Tumor Virus, Mouse/immunology, Mice, T-Lymphocytes/immunology, Th1 Cells/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:48
Dernière modification de la notice
20/08/2019 15:31
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