The functional role of the beta-subunit in the maturation and intracellular transport of Na,K-ATPase

Détails

ID Serval
serval:BIB_BD97ECA72B38
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The functional role of the beta-subunit in the maturation and intracellular transport of Na,K-ATPase
Périodique
FEBS Letters
Auteur(s)
Geering  K.
ISSN
0014-5793 (Print)
Statut éditorial
Publié
Date de publication
07/1991
Volume
285
Numéro
2
Pages
189-93
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jul 22
Résumé
The minimal functional enzyme unit of Na,K-ATPase consists of an alpha-beta complex. The alpha-subunit bears all functional domains of the enzyme and so far a regulatory role for the beta-subunit in the catalytic cycle has not been established. On the other hand, increasing experimental evidence suggests that the beta-subunit is an indispensable element for the structural and functional maturation of the enzyme as well as its intracellular transport to the plasma membrane. This brief review summarizes the experimental data supporting the hypothesis that assembly of the beta-subunit is needed for the alpha-subunit to acquire the correct, stable configuration necessary for the acquisition of functional properties and its exit from the ER.
Mots-clé
Animals Biological Transport Carrier Proteins/metabolism Endoplasmic Reticulum/enzymology Macromolecular Substances Na(+)-K(+)-Exchanging ATPase/chemistry/*metabolism *Protein Processing, Post-Translational Xenopus
Pubmed
Web of science
Création de la notice
24/01/2008 12:28
Dernière modification de la notice
20/08/2019 15:31
Données d'usage