Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_BD9481CF4AC3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms.
Périodique
Nature communications
Auteur(s)
Tchenio A., Lecca S., Valentinova K., Mameli M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
26/10/2017
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
1135
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABAB-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability-an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors.

Pubmed
Open Access
Oui
Création de la notice
09/11/2017 18:58
Dernière modification de la notice
20/08/2019 15:31
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