Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1
Détails
ID Serval
serval:BIB_BCF03AB64756
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1
Périodique
European Journal of Cancer
ISSN
0959-8049 (Print)
Statut éditorial
Publié
Date de publication
1992
Volume
28A
Numéro
11
Pages
1894-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Résumé
We analysed the effect of interleukin-1 (IL-1), IL-6 and transforming growth factor beta 1 (TGF beta 1) on the growth of a panel of eight colorectal carcinoma cell lines. IL-1 stimulated growth of two lines (LS411N and LS1034) up to 20-fold and IL-6 enhanced proliferation of LS1034 more than 5-fold. Both cytokines also augmented colony-formation of LS1034 in methylcellulose. Under both growth conditions IL-1 was the most potent stimulator. However, the addition of IL-6 to IL-1 synergistically enhanced proliferation of LS1034 in monolayer culture and additively augmented the number of colonies formed in methylcellulose. Furthermore, TGF beta 1 strongly reduced the growth rate of LS1034. Low amounts of TGF beta 1 markedly inhibited the response of LS1034 to IL-1 and totally abrogated proliferation induced by IL-6. We conclude that different cytokines can provide distinct signals for the regulation of growth of colorectal carcinoma cells.
Mots-clé
Cell Division/drug effects
Colorectal Neoplasms/*pathology
Drug Synergism
Humans
Interleukin-1/antagonists & inhibitors/*pharmacology
Interleukin-2/antagonists & inhibitors/*pharmacology
Mitosis/drug effects
Recombinant Proteins/pharmacology
Transforming Growth Factor beta/*pharmacology
Tumor Cells, Cultured/drug effects
Tumor Stem Cell Assay
Pubmed
Web of science
Création de la notice
28/01/2008 9:56
Dernière modification de la notice
20/08/2019 16:31