MYC and metastasis.

Détails

ID Serval
serval:BIB_BCE7AE9FD9F9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
MYC and metastasis.
Périodique
Cancer Research
Auteur⸱e⸱s
Wolfer A., Ramaswamy S.
ISSN
1538-7445 (Electronic)
ISSN-L
0008-5472
Statut éditorial
Publié
Date de publication
2011
Volume
71
Numéro
6
Pages
2034-2037
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a largely unresolved area of controversy. We recently found that many prognostic signatures reflect the activity of the MYC oncogene, which in turn regulates tumor metastasis through specific effects on cancer cell invasion and migration. These findings offer a general framework for understanding the molecular basis of clinically prognostic transcriptional signatures and suggest potentially new avenues for studying metastasis.
Mots-clé
Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Models, Genetic, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms/genetics, Neoplasms/metabolism, Prognosis, Proto-Oncogene Proteins c-myc/genetics, Proto-Oncogene Proteins c-myc/metabolism, Tumor Markers, Biological/genetics, Tumor Markers, Biological/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/02/2012 14:11
Dernière modification de la notice
20/08/2019 15:31
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