Causes of obesity: looking beyond the hypothalamus
Détails
ID Serval
serval:BIB_BC8E4BBC7234
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Causes of obesity: looking beyond the hypothalamus
Périodique
Progress in Neurobiology
ISSN
0301-0082 (Print)
Statut éditorial
Publié
Date de publication
02/2007
Volume
81
Numéro
2
Pages
61-88
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Résumé
The brain takes a primary position in the organism. We present the novel view that the brain gives priority to controlling its own adenosine triphosphate (ATP) concentration. It fulfils this tenet by orchestrating metabolism in the organism. The brain activates an energy-on-request system that directly couples cerebral supply with cerebral need. The request system is hierarchically organized among the cerebral hemispheres, the hypothalamus, and peripheral somatomotor, autonomic-visceromotor, and the neuroendocrine-secretomotor neurons. The system initiates allocative behavior (i.e. allocation of energy from body to brain), ingestive behavior (intake of energy from the immediate environment), or exploratory behavior (foraging in the distant environment). Cerebral projections coordinate all three behavioral strategies in such a way that the brain's energy supply is guaranteed continuously. In an ongoing learning process, the brain's request system adapts to various environmental conditions and stressful challenges. Disruption of a cerebral energy-request pathway is critical to the development of obesity: if the brain fails to receive sufficient energy from the peripheral body, it compensates for the undersupply by increasing energy intake from the immediate environment, leaving the body with a surplus. Obesity develops in the long term.
Mots-clé
Adenosine Triphosphate/metabolism
Animals
Appetite Regulation/*physiology
Brain/*physiology
*Energy Metabolism
Feedback, Biochemical/physiology
Hypothalamus
Long-Term Potentiation/physiology
Metabolic Networks and Pathways
*Models, Biological
Neural Pathways/metabolism
Obesity/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 13:16
Dernière modification de la notice
20/08/2019 15:30