Intra-aortic balloon: evaluation of heparin-coating under various experimental conditions.

Détails

ID Serval
serval:BIB_BC89890D2528
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Intra-aortic balloon: evaluation of heparin-coating under various experimental conditions.
Périodique
The International Journal of Artificial Organs
Auteur(s)
Mueller X.M., Tevaearai H.T., Von Segesser K.
ISSN
0391-3988
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
22
Numéro
9
Pages
625-628
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article - Publication Status: ppublish
Résumé
In a calf model, heparin coated intra-aortic balloon (IAB) was compared with standard balloon. In group 1, 9 of each IAB type were set to the automatic mode for 15 min, 45 min and 6 hours respectively, while in group 2, 3 of each IAB type were left deflated during 20 minutes to simulate balloon dysfunction. At the end of the procedures, 3 samples of each IAB were analyzed with scanning electron microscopy (SEM) for surface deposits. Macroscopically, the 12/12 heparin coated IAB of both groups and the 9/9 standard IAB of group 1 were free of deposits, whereas the 3/3 standard IAB of group 2 exhibited clot deposits. SEM revealed deposit-free surfaces in the 36/36 heparin coated samples of both groups, while 14/27 standard samples of group 1 (p<0.01 when compared with heparin coated samples) and 8/9 standard samples of group 2 (p = 0.02, same comparison) disclosed blood cells and fibrin deposits. Morphometrically, the proportion of standard sample surfaces covered with deposits, estimated according to a score system (0% = 0; 0.1-25% = 1; 25.1-50% = 2; 50.1-75% = 3; 75. 1-100% = 4), was 0.69+/-0.82 in group 1 (p<0.01 when compared with heparin coated samples) and 1.22+/-0.83 in group 2 (p<0.01, same comparison). Thus heparin coated IAB presents no deposits either after 6 hours of intravascular ballooning or after 20 minutes of stagnation. It seems to be a promising strategy for patients with absolute or relative contraindications to systemic heparinization.
Mots-clé
Animals, Anticoagulants/pharmacology, Cattle, Coated Materials, Biocompatible, Disease Models, Animal, Heparin/pharmacology, Intra-Aortic Balloon Pumping/instrumentation, Intra-Aortic Balloon Pumping/methods, Reference Values, Sensitivity and Specificity, Statistics, Nonparametric, Thromboembolism/prevention &amp, control
Pubmed
Web of science
Création de la notice
14/02/2008 15:17
Dernière modification de la notice
20/08/2019 16:30
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