Impact of strong psychologically stressful events on the development of Alzheimer disease: a possible role of epigenetic?

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Version: Après imprimatur
ID Serval
serval:BIB_BC587D45F4D4
Type
Mémoire
Sous-type
(Mémoire de) maîtrise (master)
Collection
Publications
Institution
Titre
Impact of strong psychologically stressful events on the development of Alzheimer disease: a possible role of epigenetic?
Auteur⸱e⸱s
EL-ACHACHI S.
Directeur⸱rice⸱s
GHIKA J.
Codirecteur⸱rice⸱s
DEMONET J.-F.
Détails de l'institution
Université de Lausanne, Faculté de biologie et médecine
Statut éditorial
Acceptée
Date de publication
2014
Langue
anglais
Nombre de pages
10
Résumé
Alzheimer disease (AD) is the most common neurodegenerative dementia. It leads to a progressive loss of cognitive functions, especially memory. Most of AD cases are sporadic, resulting from the interplay of genetic and environmental factors which get involved in the regulation of expression of thousands of genes, a mechanism called epigenetic. Epigenetic modifications, by modifying genes transcription, help to orchestrate the phenotypical changes linked to development, aging or even diseases and cancer. In AD, recent studies showed rapid, dynamic and persistent epigenetic mutations that are believed to have consequences on brain functions. One of the earliest biomarker of AD is amylo ̈ıd-beta (Aβ) deposition in the brain. According to current studies, deposition of amylo ̈ıd-beta begins approximately 20 years before the first symptoms linked to the disease which questions us about what could have happened around or before that time. In this exploratory study, we searched if there could be any correlation between the experience of a strong psychologically stressful event in life, which could have lead to several epigenetic changes and therefore the occurrence of Mild Cognitive Impairment (MCI) or AD approximately 30 years later, and to see if there is a difference in the delay between amnestic MCI and AD patients.
Mots-clé
Alzheimer disease - Epigenetics - Traumatic life events
Création de la notice
03/09/2015 10:37
Dernière modification de la notice
20/08/2019 15:30
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